132666-59-2Relevant academic research and scientific papers
SYNTHESIS OF 2-(2-ARYLETHYL)IMIDAZOLES BY DIRECT ALKYLATION OF 1-(N,N-DIMETHYLAMINOMETHYL)2-LITHIOMETHYLIMIDAZOLE
Tarnchompoo, Bongkoch,Thebtaranonth, Chachanat,Thebtaranonth, Yodhathai
, p. 5779 - 5780 (2007/10/02)
Direct deprotonation of 1-(N,N-dimethylaminomethyl)2-methylimidazole 4 by n-butyllithium yields anion 5 which can readily undergo alkylation reactions.This finding provides immediate access to 2-(2-arylethyl)imidazoles, 1, which are clumsy to prepare by other methods.
