132669-28-4

Basic information

• Product Name: 3-CHLORO-N-(3,4-DIFLUOROPHENYL)PROPANAMIDE
• Synonyms: 3-CHLORO-N-(3,4-DIFLUOROPHENYL)PROPANAMIDE;AKOS BBR-004599;3-chloro-N-(3,4-difluorophenyl)propanamide(SALTDATA: FREE);3-chloro-N-(3,4-difluorophenyl)propionamide
• CAS NO: 132669-28-4
• Molecular Formula: C₉H₈ClF₂NO
• Molecular Weight: 219.62
• Mol File: 132669-28-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 76 °C
• Boiling Point: 348.5°C at 760 mmHg
• Flash Point: 164.6°C
• Appearance: /
• Density: 1.382g/cm³
• Vapor Pressure: 5.01E-05mmHg at 25°C
• Refractive Index: 1.542
• PKA: 12.39±0.70(Predicted)
• CAS DataBase Reference: 3-CHLORO-N-(3,4-DIFLUOROPHENYL)PROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-N-(3,4-DIFLUOROPHENYL)PROPANAMIDE(132669-28-4)
• EPA Substance Registry System: 3-CHLORO-N-(3,4-DIFLUOROPHENYL)PROPANAMIDE(132669-28-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 132669-28-4(Hazardous Substances Data)

Usage

General Description

3-chloro-N-(3,4-difluorophenyl)propanamide is a chemical compound with the molecular formula C9H8ClF2NO. It is an amide derivative that contains a 3-chloro- and 3,4-difluorophenyl substituents. This chemical has potential applications in the field of pharmaceuticals and agrochemicals due to its structural features and biological activities. It may be used in the synthesis of various pharmaceutical compounds and could also have potential agricultural uses as a pesticide or fungicide. Further research is needed to fully understand the properties and potential uses of 3-chloro-N-(3,4-difluorophenyl)propanamide.

InChI:InChI=1/C9H8ClF2NO/c10-4-3-9(14)13-6-1-2-7(11)8(12)5-6/h1-2,5H,3-4H2,(H,13,14)

Upstream product

• 625-36-5 2-chloropropionyl chloride 
• 3863-11-4 3,4-difluoroaniline 

Downstream Products

• 132669-27-3 6,7-difluoro-3,4-dihydro-1H-quinolin-2-one 

Relevant articles and documents

Discovery of N-{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl] piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An allosteric muscarinic M 1 receptor agonist with unprecedented selectivity and procognitive potential

The discovery and Structure-activity relationship (SAR) of a series of allosteric muscarinic M1 receptor agonists are described. Compound 17 (Lu AE51090) was identified as a representative compound from the series, based on its high selectivity as an agonist at the muscarinic M1 receptor across a panel of muscarinic receptor subtypes. Furthermore, 17 displayed a high degree of selectivity when tested in a broad panel of G-protein-coupled receptors, ion channels, transporters, and enzymes, and 17 showed an acceptable pharmacokinetic profile and sufficient brain exposure in rodents in order to characterize the compound in vivo. Hence, in a rodent model of learning and memory, 17 reversed delay-induced natural forgetting, suggesting a procognitive potential of 17.

Synthesis and biological evaluation of benzo[b]naphthyridones, a series of new topical antibacterial agents

We describe here the synthesis and biological evaluation of a series of benzo[b]naphthyridones, a new family of tricyclic antibacterial compounds that have a Gram-positive spectrum of activity. RP60556A, one of the most potent of these compounds, is bactericidal against multiresistant cocci, especially multiresistant Staphylococcus aureus strains. Its physico-chemical and biological properties make it particularly suitable for topical antibacterial use.