1326757-20-3Relevant academic research and scientific papers
Synthesis of Tripodal Catechol Derivatives Having an Adamantyl Basic Framework for Functionalizing Surfaces
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Paragraph 0097; 0098; 0099; 0100, (2013/09/26)
The present invention describes tripodal catechol derivatives with an adamantyl basic framework for the functionalisation of surfaces, methods for their production and use. The remaining fourth bridgehead position is easily suitable to be further function
A Biomimetic principle for the chemical modification of metal surfaces: Synthesis of tripodal catecholates as analogues of siderophores and mussel adhesion proteins
Franzmann, Elisa,Khalil, Faiza,Weidmann, Christoph,Schroeder, Michael,Rohnke, Marcus,Janek, Juergen,Smarsly, Bernd M.,Maison, Wolfgang
, p. 8596 - 8603 (2011/09/19)
By following a biomimetic design principle, tetravalent scaffolds based on an adamantyl and trisalkylmethyl core structure have been synthesized. These scaffolds have been coupled to three catecholamines, thus resembling the characteristic tripodal recognition motif of many natural metal binders, such as mussel adhesion proteins and siderophores, for example, enterobactin. Besides this tripodal recognition element, our scaffolds provide a fourth position for the conjugation of effector molecules. These effectors can be conjugated through biocompatible conjugation techniques to the scaffold and can be used to tailor the properties of different metal surfaces for a range of applications, for example, in implant engineering. Herein, we describe the synthesis of several tripodal metal binders and their immobilization on TiO2 surfaces by using a simple dip-coating procedure. Furthermore, we demonstrate the conjugation of our surface binders to the dye eosin Y as an effector molecule by peptide coupling. The resulting surfaces have been analyzed by using ellipsometry, time-of-flight secondary ion mass spectrometry, IR spectroscopy, and contact-angle measurements to confirm the specific loading on TiO 2 films and nanoparticles with our trivalent surface binders. As a proof of concept, we have demonstrated the functionalization of TiO2 nanoparticles with the eosin Y dye.
