1326777-35-8Relevant articles and documents
SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-xL and Mcl-1
Rega, Michele F.,Wu, Bainan,Wei, Jun,Zhang, Ziming,Cellitti, Jason F.,Pellecchia, Maurizio
, p. 6000 - 6013 (2011/10/09)
Overexpression of antiapoptotic members of the Bcl-2 family proteins, such as Bcl-xL and Mfl-1, has been shown to be involved in resistance to chemotherapeutic drugs in many forms of cancers. Recent efforts from the Abbott Laboratories resulted