6-METHOXYISOINDOLIN-1-ONE is an organic compound that serves as a crucial reagent in the synthesis of various chemical compounds with potential applications in the pharmaceutical industry. It is characterized by its unique chemical structure, which allows it to participate in a range of reactions and contribute to the development of new drugs with therapeutic properties.
132680-54-7
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Basic information
- Product Name: 6-METHOXYISOINDOLIN-1-ONE
- Synonyms: 6-METHOXYISOINDOLIN-1-ONE;6-METHOXYISOINDOLINONE;1H-Isoindol-1-one, 2,3-dihydro-6-Methoxy-;6-Methoxy-2,3-dihydro-1H-isoindol-1-one;6-METHOXY-2,3-DIHYDRO-ISOINDOL-1-ONE;3-dihydro-1H-isoindol-1-one;2,3-Dihydro-6-methoxy-1H-isoindol-1-one
- CAS NO:132680-54-7
- Molecular Formula: C9H9NO2
- Molecular Weight: 163.17
- EINECS: N/A
- Product Categories: N/A
- Mol File: 132680-54-7.mol
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Chemical Properties
- Melting Point: 189-190 °C(Solv: ethyl acetate (141-78-6))
- Boiling Point: 428.012 °C at 760 mmHg
- Flash Point: 212.654 °C
- Appearance: /
- Density: 1.208 g/cm3
- Vapor Pressure: 0mmHg at 25°C
- Refractive Index: 1.565
- Storage Temp.: Sealed in dry,Room Temperature
- Solubility: N/A
- PKA: 14.37±0.20(Predicted)
- CAS DataBase Reference: 6-METHOXYISOINDOLIN-1-ONE(CAS DataBase Reference)
- NIST Chemistry Reference: 6-METHOXYISOINDOLIN-1-ONE(132680-54-7)
- EPA Substance Registry System: 6-METHOXYISOINDOLIN-1-ONE(132680-54-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 132680-54-7(Hazardous Substances Data)
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132680-54-7 Usage
Uses
Used in Pharmaceutical Industry:6-METHOXYISOINDOLIN-1-ONE is used as a reagent for the synthesis of novel isoindolinone derivatives, which possess significant anti-tumor activity. These derivatives are being explored for their potential in treating various types of cancer, offering new avenues for cancer therapy.
6-METHOXYISOINDOLIN-1-ONE is also used in the preparation and optimization of 2-aminothiazole 4-carboxamides, which are being investigated as new CHK1 inhibitors. CHK1 inhibitors are a class of compounds that have shown promise in the treatment of cancer by targeting the cell cycle checkpoint kinase 1, a protein that plays a crucial role in cell division and DNA damage response. By inhibiting CHK1, these compounds can potentially disrupt cancer cell growth and induce cell death, making them a valuable target for cancer therapeutics.
Check Digit Verification of cas no
The CAS Registry Mumber 132680-54-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,6,8 and 0 respectively; the second part has 2 digits, 5 and 4 respectively.Calculate Digit Verification of CAS Registry Number 132680-54:
(8*1)+(7*3)+(6*2)+(5*6)+(4*8)+(3*0)+(2*5)+(1*4)=117
117 % 10 = 7
So 132680-54-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H9NO2/c1-12-7-3-2-6-5-10-9(11)8(6)4-7/h2-4H,5H2,1H3,(H,10,11)
132680-54-7Upstream product
132680-54-7Downstream Products
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6-METHOXYISOINDOLIN-1-ONE
