13269-48-2Relevant articles and documents
Linkers for the synthesis of multiple oligonucleotides in seriatim from a single support attachment
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, (2008/06/13)
A method for the synthesis of a plurality of oligonucleotides comprising the steps of (i) forming a first oligonucleotide on a first cleavable link attached to a solid support; (ii) attaching to the first oligonucleotide a cleavable linker moiety; (iii) forming a second oligonucleotide on the cleavable linker moiety; and (iv) cleaving the first cleavable link and the cleavable linker moiety to give a plurality of oligonucleotides; wherein the cleavable linker moiety is of the Formula (1): STR1 in which A1, A2 and E are as defined herein, and novel compounds which may be used in the operation of the method.