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132695-96-6

**2-Pyrrolidinone,3-amino-1-hydroxy-4-methyl-,(3S-cis)-(9CI) (L-687,414)** is a structurally rigid compound used as a template in the design of strychnine-insensitive glycine receptor ligands targeting the NMDA receptor. It serves as a reference for pharmacophore spatial orientation, contributing to the development of compounds with potential therapeutic applications in neurological and psychiatric disorders. However, structural modifications to its framework, such as ring expansion or substitution, often result in reduced activity, highlighting its importance as a foundational scaffold in ligand design.

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  • 132695-96-6 Structure

  • Basic information

    1. Product Name: 2-Pyrrolidinone,3-amino-1-hydroxy-4-methyl-,(3S-cis)-(9CI)
    2. Synonyms: 2-Pyrrolidinone,3-amino-1-hydroxy-4-methyl-,(3S-cis)-(9CI);L 687414;(3R)-3α-Amino-1-hydroxy-4α-methyl-2-pyrrolizinone
    3. CAS NO:132695-96-6
    4. Molecular Formula: C5H10N2O2
    5. Molecular Weight: 130.15
    6. EINECS: N/A
    7. Product Categories: PYRROLIDINE;AMINEPRIMARY
    8. Mol File: 132695-96-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 253.7°Cat760mmHg
    3. Flash Point: 107.3°C
    4. Appearance: /
    5. Density: 1.29g/cm3
    6. Vapor Pressure: 0.00277mmHg at 25°C
    7. Refractive Index: 1.547
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-Pyrrolidinone,3-amino-1-hydroxy-4-methyl-,(3S-cis)-(9CI)(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-Pyrrolidinone,3-amino-1-hydroxy-4-methyl-,(3S-cis)-(9CI)(132695-96-6)
    12. EPA Substance Registry System: 2-Pyrrolidinone,3-amino-1-hydroxy-4-methyl-,(3S-cis)-(9CI)(132695-96-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 132695-96-6(Hazardous Substances Data)

132695-96-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 132695-96-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,6,9 and 5 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 132695-96:
(8*1)+(7*3)+(6*2)+(5*6)+(4*9)+(3*5)+(2*9)+(1*6)=146
146 % 10 = 6
So 132695-96-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H10N2O2/c1-3-2-7(9)5(8)4(3)6/h3-4,9H,2,6H2,1H3/t3-,4-/m0/s1

132695-96-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name (3S,4S)-3-amino-1-hydroxy-4-methylpyrrolidin-2-one

1.2 Other means of identification

Product number -
Other names cis-4-Methyl-HA-966

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:132695-96-6 SDS

132695-96-6Downstream Products

132695-96-6Relevant articles and documents

Routes to 4-Substituted Analogues of the Glycine/NMDA Antagonist HA-966. Enantioselective Synthesis of (3R,4R) 3-Amino-1-Hydroxy-4-Methyl-2-Pyrrolidinone (L-687,414).

Rowley, Michael,Leeson, Paul D.,Williams, Brian J.,Moore, Kevin W.,Baker, Raymond

, p. 3557 - 3570 (2007/10/02)

Glycine anion (4) and glycine cation (8) synthons are used in efficient synthesis of 4-substituted analogues of HA-966 (1).A stereospecific route to cis derivatives involves hydrogenation of enamines such as 16.Introduction of a chiral auxiliary leads to

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