132697-88-2Relevant academic research and scientific papers
Synthesis of "Garner" aldehyde-derived cyclopropylboronic esters
Pietruszka, Joerg,Witt, Andreas,Frey, Wolfgang
, p. 3219 - 3229 (2007/10/03)
The "Garner" aldehyde has been used as a common intermediate for the preparation of the corresponding alkyne 7 and the alkenylboronic esters 12-16 (24-80%). Diastereoselective cyclopropanation afforded cyclopropylboronic esters 17-20 (60-84%, dr 22:78 to 92:8), the configurations of which were determined by chemical correlation (cyclopropanols 22), X-ray structural analysis (of 21a), and characteristic NMR spectroscopic data. The protected amino alcohols 23-26 and amino acids 27 have been synthesised from the cyclopropylboronic esters 19 by oxidation, Matteson homologation or Suzuki coupling. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
SYNTHESIS OF ASYMMETRIC (E)-α-GLYCINES FROM SERINE BY DIASTEREOSELECTIVE DIBROMOCYCLOPROPANATION
Frutos, Pilar de,Fernandez, Dolores,Fernandez-Alvarez, E.,Bernabe, Manuel
, p. 1123 - 1130 (2007/10/02)
An asymmetric synthesis of (E)-α-2-phenylcyclopropyl)glycines and also of a homolog of allocoronamic acid, namely (E)-α-(2-ethylcyclopropyl)glycine, is reported.The key step is the dibromocyclopropanation of tert-butyl (E, 4R)- or (E, 4S)-2,2-dimethyl-4-
Synthesis of asymmetric (E)-α-(2-phenylcyclopropyl)glycines
De Frutos,Fernandez,Fernandez-Alvarez,Bernabe
, p. 541 - 542 (2007/10/02)
An asymmetric synthesis of (E)-α-(2-phenylcyclopropyl)glycines is reported. The key step is the dibromocyclopropanation of tert-Butyl (E,4R) or (E,4S)-2,2-dimethyl-4-(2'-phenylvinyl)-3-oxazolidinecarboxylates, easily prepared from L or D-serine, respectiv
