132727-07-2Relevant academic research and scientific papers
A temperature study on a stereoselective organocatalyzed aldol reaction in water
Emer, Enrico,Galletti, Paola,Giacomini, Daria
, p. 11205 - 11208 (2008)
We report the first temperature study on the stereoselectivity of the 'in-water' aldol reaction between nicotinaldehyde (3-pyridinecarbaldehyde) and cyclohexanone catalyzed by morpholine and trans-4-tert-butyldimethylsilyloxy-l-proline. Eyring plots of diastereomeric ratio anti/syn gave a constant diastereoselectivity with respect to reaction temperature using morpholine as catalyst. With O(TBS)-l-proline we observed a non-linear behaviour of the Eyring plot with the presence of an inversion temperature (Tinv), which disclosed dynamic solvation effects in water.
Design, synthesis, and photoluminescence properties of one-, two-, and three-dimensional coordination polymers: Anion-assisted argentophillic interactions as building blocks
Banerjee, Kaustuv,Roy, Sandipan,Biradha, Kumar
, p. 5164 - 5170 (2014)
Five new Ag(I) complexes of the formulae {[Ag2(L1)2(NDS)]3H2O}n (1), {[Ag2(L2)2(NDS)]·2H2O}n (2), {[Ag3(L2)2(IQS)2]·(NO3)·4H2O·2MeOH}n (3), {[Ag2(L3)2(NDS)]·4H2O}n (4), and {[Ag2(L3)2(IQS)]·(NO3)·H2O}n (5) (L1 = 2,5-bis-pyridine-3-ylmethylene-cyclopentanone, L2 = 2,5-bis-pyridine-3-ylmethylene-cyclohexanone, L3 = 2,5-bis-pyridine-4-ylmethylene-cyclopentanone, NDS = naphthalene disulfonate, and IQS = isoquinoline-5-sulfonate) have been synthesized and characterized by elemental analysis, IR, powder X-ray diffraction, and single-crystal X-ray diffraction. Complexes 1-3 were found to have sulfonate supported Ag...Ag interaction, and the sulfonate ions act as linkers to form higher dimensional networks (ladder, two- and three-dimensional networks). The complexes 4 and 5, which contain 4-pyridyl substitution, do not form such Ag...Ag interactions, indicating a clear tendency of 3-pyridyl derivatives to promote such interactions over 4-pyridyl derivatives. This observation was also evidenced by the analysis of Ag(I) complexes in Cambridge Structural Database. Further, complexes 1-5 were found to exhibit solid-state photoluminescence in the green region at room temperature.
SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR PROTEINS AND THEIR USE IN THE TREATMENT OF CANCER
-
Page/Page column 34, (2016/08/03)
Small molecule stimulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing cancer. Also provided are methods for stimulating SRC family proteins in a cell.
