1327310-72-4Relevant academic research and scientific papers
Piperazine derivatives and the use thereof as medicament
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, (2015/04/21)
The present inventions relate to substituted piperazine derivatives of general formula (I) and to the manufacture of said compounds, pharmaceutical compositions comprising a compound according to general formula (I), and the use of said compounds for the treatment of various medical conditions related to glycine transporter-1 (GlyT1).
PIPERAZINE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT
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, (2015/05/05)
The present inventions relate to substituted piperazine derivatives of general formula (I) and to the manufacture of said compounds, pharmaceutical compositions comprising a compound according to general formula (I), and the use of said compounds for the treatment of various medical conditions related to glycine transporter-1 (GlyT1).
Dynamic resolution of α-halo chiral esters for the synthesis of 3-substituted piperazin-2-ones
Jang, Jung In,Kang, Seock Yong,Kang, Kyoung Hee,Park, Yong Sun
, p. 6221 - 6226 (2011/09/19)
Dynamic resolution of α-halo esters derived from five chiral alcohols has been investigated in nucleophilic substitution with ethylenediamine nucleophiles. Stereoselective substitution of α-halo esters and following spontaneous cyclization provide a pract
