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132741-30-1

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132741-30-1 Usage

General Description

2,4-Difluoromandelic acid is a chemical compound with the molecular formula C8H6F2O4. It is a derivative of mandelic acid with two fluorine atoms attached in the para position on the phenyl ring. 2,4-DIFLUOROMANDELIC ACID has been studied for its potential use in pharmaceuticals and as a building block in organic synthesis. It exhibits interesting properties due to the presence of the fluorine atoms, which can affect its reactivity and interactions with other molecules. Its potential applications include its use as a chiral resolving agent, as a precursor in the synthesis of fluorinated compounds, and as a starting material for the production of pharmaceuticals.

Check Digit Verification of cas no

The CAS Registry Mumber 132741-30-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,7,4 and 1 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 132741-30:
(8*1)+(7*3)+(6*2)+(5*7)+(4*4)+(3*1)+(2*3)+(1*0)=101
101 % 10 = 1
So 132741-30-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H6F2O3/c9-4-1-2-5(6(10)3-4)7(11)8(12)13/h1-3,7,11H,(H,12,13)/p-1/t7-/m1/s1

132741-30-1 Well-known Company Product Price

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  • Alfa Aesar

  • (L10708)  2,4-Difluoromandelic acid, 97%   

  • 132741-30-1

  • 1g

  • 798.0CNY

  • Detail
  • Alfa Aesar

  • (L10708)  2,4-Difluoromandelic acid, 97%   

  • 132741-30-1

  • 5g

  • 2856.0CNY

  • Detail

132741-30-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(2,4-Difluorophenyl)-2-hydroxyacetic acid

1.2 Other means of identification

Product number -
Other names 2-(2,4-difluorophenyl)-2-hydroxyacetic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:132741-30-1 SDS

132741-30-1Relevant articles and documents

Semirational Design of Fluoroacetate Dehalogenase RPA1163 for Kinetic Resolution of α-Fluorocarboxylic Acids on a Gram Scale

Chen, Bo,Li, Min,Li, Yanwei,Ma, Ming,Tian, Shaixiao,Tong, Wei,Wang, Jian-Bo,Xu, Guangyu,Yue, Yue,Zhang, Hongxia

, p. 3143 - 3151 (2020/03/23)

Here the synthetic utility of fluoroacetate dehalogenase RPA1163 is explored for the production of enantiomerically pure (R)-α-fluorocarboxylic acids and (R)-α-hydroxylcarboxylic acids via kinetic resolution of racemic α-fluorocarboxylic acids. While wild-type (WT) RPA1163 shows high thermostability and fairly wide substrate scope, many interesting yet poorly or moderately accepted substrates exist. In order to solve this problem and to develop upscaled production, in silico calculations and semirational mutagenesis were employed. Residue W185 was engineered to alanine, serine, threonine, or asparagine. The two best mutants, W185N and W185T, showed significantly improved performance in the reactions of these substrates, while in silico calculations shed light on the origin of these improvements. Finally, 10 α-fluorocarboxylic acids and 10 α-hydroxycarboxylic acids were prepared on a gram scale via kinetic resolution enabled by WT, W185T, or W185N. This work expands the biocatalytic toolbox and allows a deep insight into the fluoroacetate dehalogenase catalyzed C-F cleavage mechanism.

Enzymatic Resolution by a d-Lactate Oxidase Catalyzed Reaction for (S)-2-Hydroxycarboxylic Acids

Sheng, Binbin,Xu, Jing,Ge, Yongsheng,Zhang, Shuo,Wang, Danqi,Gao, Chao,Ma, Cuiqing,Xu, Ping

, p. 2630 - 2633 (2016/08/30)

Oxidase-catalyzed kinetic resolution is important for the production of enantiopure 2-hydroxycarboxylic acids (2-HAs), which are versatile building blocks for the synthesis of many significant compounds. However, in contrast to that of (R)-2-HAs, the production of (S)-2-HA is challenging because of the lack of related oxidases. Herein, suitable enzymes were screened systematically through the analysis of numerous putative d-lactate oxidase sequences and identification of several required properties. Finally, a d-lactate oxidase from Gluconobacter oxydans 621H with advantageous characteristics, such as good solubility, broad substrate spectrum, and high stereoselectivity, was selected to resolve 2-HAs into (S)-2-HAs. A variety of (S)-2-HAs was produced successfully using this d-lactate oxidase with excellent enantiomeric excess values (>99 %). The presented screening criteria and approach for target biocatalysis suggested a guideline for the production of optically active chemicals such as (S)-2-HAs.

One-pot, single-step deracemization of 2-hydroxyacids by tandem biocatalytic oxidation and reduction

Xue, Ya-Ping,Zheng, Yu-Guo,Zhang, Ya-Qin,Sun, Jing-Lei,Liu, Zhi-Qiang,Shen, Yin-Chu

supporting information, p. 10706 - 10708 (2013/11/06)

A facile and efficient one-pot, single-step method for deracemizing a broad range of 2-hydroxyacids to (R)-2-hydroxyacids was established by combination of resting cells of an (S)-hydroxyacid dehydrogenase-producing microorganism and an (R)-ketoacid reductase-producing microorganism.

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