132776-28-4 Usage
Uses
Used in Medicinal Chemistry:
2,2-Anhydro-5-O-trityl-3-O-(1-imidazoyl(thiocarbonyl))thymidine is employed as a key intermediate in the synthesis of nucleoside analogs, which are crucial for the development of new antiviral and anticancer drugs. Its unique thiol functionality allows for the creation of novel nucleotide structures with enhanced biological activity and selectivity.
Used in Drug Discovery:
In the field of drug discovery, 2,2-Anhydro-5-O-trityl-3-O-(1-imidazoyl(thiocarbonyl))thymidine serves as a valuable building block for the design and synthesis of innovative nucleotide analogs. These analogs are evaluated for their potential therapeutic effects against various viral and cancerous diseases, contributing to the advancement of new treatment options.
Used in Pharmaceutical Studies:
2,2-Anhydro-5-O-trityl-3-O-(1-imidazoyl(thiocarbonyl))thymidine is utilized as a fundamental component in pharmaceutical studies, where it aids in the exploration of the structure-activity relationships of nucleoside analogs. This understanding is essential for optimizing the potency, selectivity, and pharmacokinetic properties of these compounds, ultimately leading to the development of more effective medications.
Used in Nucleoside and Nucleotide Chemistry:
2,2-Anhydro-5-O-trityl-3-O-(1-imidazoyl(thiocarbonyl))thymidine is also used as a research tool in the field of nucleoside and nucleotide chemistry, where its unique structure and reactivity are harnessed to investigate the fundamental principles governing the synthesis and biological activity of nucleic acid derivatives. This research contributes to the broader understanding of nucleic acid chemistry and its applications in medicine and biotechnology.
Check Digit Verification of cas no
The CAS Registry Mumber 132776-28-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,7,7 and 6 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 132776-28:
(8*1)+(7*3)+(6*2)+(5*7)+(4*7)+(3*6)+(2*2)+(1*8)=134
134 % 10 = 4
So 132776-28-4 is a valid CAS Registry Number.
132776-28-4Relevant academic research and scientific papers
Fluorinated sugar analogues of potential anti-HIV-1 nucleosides
Huang,Chen,Wang,Kim,Warshaw,Armstrong,Zhu,Chou,Watanabe,Matulic-Adamic,Su,Fox,Polsky,Baron,Gold,Hardy,Zuckerman
, p. 1640 - 1646 (2007/10/02)
In order to obtain agents with therapeutic indices superior to those of AZT, FLT, or D4T, several analogues of anti-HIV-1 nucleosides were synthesized. These include 2',3'-dideoxy-2',3'-difluoro-5-methyluridine (13), its arabino analogue 19, arabino-5-met
