132784-94-2Relevant academic research and scientific papers
Enantioselective synthesis of 2,3-dihydrofurans using a bifunctional quinine/squaramide organocatalyst
Bozdemir, Merve,Gündo?du, Gülsüm,Susam, Zeynep Dil?ad,Tanyeli, Cihangir
, p. 599 - 606 (2022/01/22)
Asymmetric organocatalytic domino type Michael-SN2 reactions give access to enantiomerically enriched dihydrofuran derivatives that can be used as valuable chiral building blocks. A variety of α-bromonitroalkenes and 1,3-dicarbonyl compounds were allowed to react under optimized conditions, in the presence of a bifunctional quinine-derived sterically encumbered squaramide (H-bond donor) organocatalyst. The conditions developed in this article have great advantages over the methods known in the literature in terms of reaction duration (1-6 h vs. 24-96 h) and reaction temperature (room temperature vs. -20 °C to -50 °C) giving rise to quite diastereoselective products with good enantioselectivities up to 97% ee.
Potassium Fluoride-Promoted Reaction of (2-Chloro-2-nitroethenyl)benzenes with 1,3-Dicarbonyl Compounds. A General Synthesis of 6,6-Dimethyl-2-nitro-3-phenyl-3,5,6,7-tetrahydro-4(2H)benzofuranones and some Analogs
Dauzonne, Daniel,Demerseman, Pierre
, p. 1581 - 1584 (2007/10/02)
A convenient procedure to prepare in good yields 6,6-dimethyl-2-nitro-3-phenyl-3,5,6,7-tetrahydro-4(2H)benzofuranones starting from (2-chloro-2-nitroethenyl)benzenes and 5,5-dimethyl-1,3-cyclohexanedione in the presence of potassium fluoride is reported.T
