132794-08-2

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-2,5-DIFLUOROBENZOYL CHLORIDE is used as a key intermediate in the synthesis of fluoroquinolone antibiotics, which are a class of broad-spectrum antibiotics effective against a wide range of bacterial infections. Its presence in the synthesis process contributes to the development of these potent antimicrobial agents.
Used in Agrochemical Industry:
4-CHLORO-2,5-DIFLUOROBENZOYL CHLORIDE is utilized as a precursor in the manufacturing of various agrochemicals, including insecticides, herbicides, and fungicides. Its role in the production of these compounds helps in the development of effective pest control solutions for agricultural applications.
Safety Precautions:
Due to its highly corrosive and hazardous nature, 4-CHLORO-2,5-DIFLUOROBENZOYL CHLORIDE should be handled and stored with extreme caution. Appropriate safety measures, including the use of personal protective equipment and adherence to proper handling protocols, are essential when working with this chemical to minimize the risk of accidents and ensure the safety of personnel and the environment.

Upstream product

• 132794-07-1 4-chloro-2,5-difluoro-benzoic acid 

Downstream Products

• 884534-33-2 methyl 3-[(4-chloro-2,5-difluorobenzoyl)amino]thiophene-2-carboxylate 
• 1416785-13-1 4-chloro-2,5-difluoro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]benzamide 
• 1620847-91-7 4-chloro-2,5-difluoro-N-(2-oxo-1,2-dihydropyridin-4-yl)benzamide 
• 1620847-14-4 4-chloro-2-(2-chloro-4-fluorophenoxy)-5-fluoro-N-(2-oxo-1,2-dihydropyridin-4-yl)benzamide 
• 1620847-92-8 4-chloro-2,5-difluoro-N-(2-methoxy-4-pyridyl)benzamide 
• 1456616-37-7 C₁₂H₈ClF₂NO₃ 
• 1456616-33-3 C₈H₄ClF₂NO₃ 
• 1416785-15-3 4-chloro-2,5-difluoro-N-[(1R)-2,2,2-trifluoro-1-methylethyl]benzamide 

Relevant academic research and scientific papers

Structure-activity relationships of agonists for the orphan G protein-coupled receptor GPR27

GPR27 belongs, with GPR85 and GPR173, to a small subfamily of three receptors called “Super-Conserved Receptors Expressed in the Brain” (SREB). It has been postulated to participate in key physiological processes such as neuronal plasticity, energy metabolism, and pancreatic β-cell insulin secretion and regulation. Recently, we reported the first selective GPR27 agonist, 2,4-dichloro-N-(4-(N-phenylsulfamoyl)phenyl)benzamide (I, pEC50 6.34, Emax 100%). Here, we describe the synthesis and structure-activity relationships of a series of new derivatives and analogs of I. All products were evaluated for their ability to activate GPR27 in an arrestin recruitment assay. As a result, agonists were identified with a broad range of efficacies including partial and full agonists, showing higher efficacies than the lead compound I. The most potent agonist was 4-chloro-2,5-difluoro-N-(4-(N-phenylsulfamoyl)phenyl)benzamide (7y, pEC50 6.85, Emax 37%), and the agonists with higher efficacies were 4-chloro-2-methyl-N-(4-(N-phenylsulfamoyl)phenyl)benzamide (7p, pEC50 6.04, Emax 123%), and 2-bromo-4-chloro-N-(4-(N-phenylsulfamoyl)phenyl)benzamide (7r, pEC50 5.99, Emax 123%). Docking studies predicted the putative binding site and interactions of agonist 7p with GPR27. Selected potent agonists were found to be soluble and devoid of cellular toxicity within the range of their pharmacological activity. Therefore, they represent important new tools to further characterize the (patho)physiological roles of GPR27.

Discovery and biological evaluation of novel 4-amino-2-phenylpyrimidine derivatives as potent and orally active GPR119 agonists

Novel 4-amino-2-phenylpyrimidine derivatives were synthesized and evaluated as GPR119 agonists. Optimization of the substituents on the phenyl ring at the 2-position and the amino group at the 4-position led to the identification of 3,4-dihalogenated and

AROMATIC-RING-FUSED PYRIMIDINE DERIVATIVE

There are provided novel pyrimidine derivatives which has been fused with an aromatic heterocycle selected from thiophene, thiazole and pyridine or pharmaceutically acceptable salts thereof; and a pharmaceutical composition comprising said compound as an

Novel intermediates for the production of 2,4,5-trifluorobenzoyl fluoride

The present invention comprises compounds of the formulas: STR1 wherein X is Cl or Br. These compounds are useful as intermediaries for the production of 2,4,5-trifluorobenzoic acid and 2,4,5-trifluorobenzoyl fluoride.