13281-03-3

Usage

Uses

Used in Lubricant Industry:
1-Octyl-2-thiourea is used as a corrosion inhibitor in lubricants to prevent the degradation of metal components, thereby extending the life of machinery and reducing maintenance costs.
Used in Chemical Synthesis:
As a chemical intermediate, 1-Octyl-2-thiourea plays a crucial role in the synthesis of other compounds, contributing to the development of new materials and products.
Used in Pharmaceutical Production:
1-Octyl-2-thiourea is utilized in the production of pharmaceuticals, where its unique properties may contribute to the formulation of new drugs or the enhancement of existing ones.
Used in Agricultural Chemicals:
1-OCTYL-2-THIOUREA is also employed in the creation of agricultural chemicals, potentially improving crop yields and protection against pests.
Used in Heavy Metal Poisoning Treatment:
1-Octyl-2-thiourea has been studied for its potential use in treating heavy metal poisoning, suggesting it may have detoxifying properties.
Used in Photography:
As a sensitizing agent in photography, 1-Octyl-2-thiourea enhances the sensitivity of photographic materials to light, improving the quality and efficiency of the imaging process.
It is important to handle 1-Octyl-2-thiourea with care due to its potential harmful effects if ingested, inhaled, or absorbed through the skin, emphasizing the need for proper safety measures during its use and storage.

InChI:InChI=1/C9H20N2S/c1-2-3-4-5-6-7-8-11-9(10)12/h2-8H2,1H3,(H3,10,11,12)

Upstream product

• 117759-83-8 (1-Benzotriazol-1-yl-octyl)-thiourea 
• 1147550-11-5 ammonium thiocyanate 
• 142-95-0 n-octylamine hydrochloride 
• 111-86-4 n-Octylamine 
• 17356-08-0 thiourea 
• 124-13-0 Octanal 

Downstream Products

• 4430-45-9 n-octylisothiocyanate 

Relevant academic research and scientific papers

ISOTHIOCYANATE PRODUCTION METHOD, COMPOSITION FOR TRANSPORTING AND STORING N-SUBSTITUTED O-SUBSTITUTED THIOCARBAMATE, AND ISOTHIOCYANATE COMPOSITION

The present invention relates to an isothiocyanate production method using an organic primary amine and thiourea as starting materials; to a composition for transporting and storing an N-substituted O-substituted thiocarbamate that includes an N-substituted O-substituted thiocarbamate and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the carbamate groups of the N-substituted O-substituted thiocarbamate being in the range of 1 to 100; to a composition for transporting and storing a compound with a thioureido group that includes a compound with a thioureido group and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the thioureido groups of the compound with a thioureido group being in the range of 1 to 100; and to an isothiocyanate composition containing an isothiocyanate and a compound with a specific functional group.

ISOTHIOCYANATE PRODUCTION METHOD, COMPOSITION FOR TRANSPORTING AND STORING N-SUBSTITUTED O-SUBSTITUTED THIOCARBAMATE, AND ISOTHIOCYANATE COMPOSITION

The present invention relates to an isothiocyanate production method using an organic primary amine and thiourea as starting materials; to a composition for transporting and storing an N-substituted O-substituted thiocarbamate that includes an N-substituted O-substituted thiocarbamate and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the carbamate groups of the N-substituted O-substituted thiocarbamate being in the range of 1 to 100; to a composition for transporting and storing a compound with a thioureido group that includes a compound with a thioureido group and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the thioureido groups of the compound with a thioureido group being in the range of 1 to 100; and to an isothiocyanate composition containing an isothiocyanate and a compound with a specific functional group.

Substituted 5,5′-diphenyl-2-thioxoimidazolidin-4-one as CB 1 cannabinoid receptor ligands: Synthesis and pharmacological evaluation

A set of 30 substituted 5,5′-diphenyl-2-thioxoimidazolidin-4-one (thiohydantoins) derivatives was synthesized, and their affinity for the human CB1 cannabinoid receptor has been evaluated. These compounds are derived from the previously described cannabinoid ligands 5,5′- diphenylimidazolidine-2,4-dione (hydantoins). The replacement of the oxygen by a sulfur leads to an increase of the affinity while the function-i.e., inverse agonism-determined by [35S]-GTPγS experiments remains unaffected. Finally, to evaluate the molecular parameters that could influence the affinity of the thiohydantoins, molecular electrostatic potential as well as lipophilicity calculations were undertaken on representative thiohydantoins and hydantoins derivatives. In conclusion, 5,5′-bis-(4-iodophenyl)-3-butyl-2- thioxoimidazolidin-4-one (31) and 3-allyl-5,5′-bis(4-bromophenyl)-2- thioxoimidazolidin-4-one (32) possess the highest affinity for the CB 1 cannabinoid receptor described to date for the hydantoin and thiohydantoins series when compared in a same bioassay.

A GENERAL METHOD FOR THE N-ALKYLATION OF THIOAMIDES.

Thioamides are N-alkylated in a two-step procedure: (i) Reaction with an aldehyde and benzotriazole yields an adduct which is (ii) reduced to the N-alkylthioamide by NaBH4.