132853-85-1

Usage

Chemical class

Triazolo cinnoline derivative

Structure

Contains a 1,3-dione moiety and a 2-phenyl substituent

Substituent

1-oxopropyl group attached to the 5-position of the cinnoline ring

Potential applications

Pharmaceutical or biological applications

Research area

Medicinal chemistry and drug development

Further studies needed

To fully understand its properties and potential uses

Upstream product

• 4233-33-4 4-Phenyl-1,2,4-triazolidine-3,5-dione 
• 132853-84-0 6-(3,5-Dioxo-4-phenyl-[1,2,4]triazolidin-1-yl)-2-phenyl-5-propionyl-5,6-dihydro-[1,2,4]triazolo[1,2-a]cinnoline-1,3-dione 
• 3152-68-9 (1E)-1-phenylpent-1-en-3-one 

Relevant academic research and scientific papers

Base-Induced Addition-Elimination Reactions of Electron-Deficient Vinylarenes Containing a Carbonyl or Ester Group Utilizing 4-Phenyl-3H-1,2,4-triazole-3,5(4H)-dione (PTAD)

The reaction of electron-deficient vinylarenes such as styrylketones and cinnamate with PTAD afforded double Diels-Alder products and Diels-Alder ene products; the latter underwent novel base-induced elimination of 4-phenyl-1,2,4-triazoline-3,5-dione via a stable carbanion.

Novel Base-promoted Addition-Elimination Reaction of Electron-deficient Benzylidene Derivatives with N-Phenyl-1,2,4-triazole-3,5-dione (PTAD)

The reaction of electron-deficient benzylidene derivatives with PTAD afforded the double Diels-Alder product and the Diels-Alder ene product; the latter underwent novel base-induced elimination of phenyl urazole via a stable carbanion.