13286-73-2Relevant articles and documents
Cobalt-catalyzed cross-coupling reaction between functionalized primary and secondary alkyl halides and aliphatic Grignard reagents
Cahiez, Gerard,Chaboche, Christophe,Duplais, Christophe,Giulliani, Arianna,Moyeux, Alban
supporting information; experimental part, p. 1484 - 1488 (2009/07/01)
The coupling of primary and secondary unactivated alkyl bromides with alkyl-Grignard reagents was performed in good yields under mild conditions by using a new catalytic system: consisting of cobalt chloride and tetramethylethylenediamine (CoCl2·2 LiI, 4TMEDA). The reaction is very chemoselective since ketone, ester and nitrile functions are tolerated.