132864-57-4

Basic information

• Product Name: 3-(MethylsulfonaMido)-2-thiophenecarboxylic Acid
• Synonyms: 3-(MethylsulfonaMido)-2-thiophenecarboxylic Acid;3-[(methylsulfonyl)amino]-2-Thiophene carbocylic acid;3-[(methylsulfonyl)amino]- 2-Thiophenecarboxylic acid;3-(Methylsulfonamido)thiophene-2-carboxylic acid
• CAS NO: 132864-57-4
• Molecular Formula: C6H7NO4S2
• Molecular Weight: 221.25408
• Mol File: 132864-57-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(MethylsulfonaMido)-2-thiophenecarboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(MethylsulfonaMido)-2-thiophenecarboxylic Acid(132864-57-4)
• EPA Substance Registry System: 3-(MethylsulfonaMido)-2-thiophenecarboxylic Acid(132864-57-4)

Safety Data

• Hazardous Substances Data: 132864-57-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3-(MethylsulfonaMido)-2-thiophenecarboxylic Acid serves as a key building block for the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides to treat a range of diseases and control pests in agriculture.
Used in Biochemical and Pharmaceutical Research:
This chemical compound is utilized as a research reagent in biochemical and pharmaceutical research, aiding scientists in understanding its properties and potential applications in the development of therapeutic agents.
Handling and Storage:
Due to its potential hazards, 3-(MethylsulfonaMido)-2-thiophenecarboxylic Acid is typically handled and stored under controlled conditions to ensure safety and stability.

Upstream product

• 79128-71-5 methyl 3-(methylsulfonamido)thiophene-2-carboxylate 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 

Relevant articles and documents

Synthesis and SAR studies of novel 1,2,4-oxadiazole-sulfonamide based compounds as potential anticancer agents for colorectal cancer therapy

A diverse series of 1,2,4-oxadiazoles based substituted compounds were designed, synthesized and evaluated as anticancer agents targeting carbonic anhydrase IX (CAIX). Initial structure-activity analysis suggested that the thiazole/thiophene-sulfonamide conjugates of 1,2,4-oxadiazoles exhibited potent anticancer activities with low μM potencies. Compound OX12 exhibited antiproliferative activity (IC50 = 11.1 μM) along with appreciable inhibition potential for tumor-associated CAIX (IC50 = 4.23 μM) isoform. Therefore, OX12 was structurally optimized and its SAR oriented derivatives (OX17-27) were synthesized and evaluated. This iteration resulted in compound OX27 with an almost two-fold increase in antiproliferative effect (IC50 = 6.0 μM) comparable to the clinical drug doxorubicin and significantly higher potency against CAIX (IC50 = 0.74 μM). Additionally, OX27 treatment decreases the expression of CAIX, induces apoptosis and ROS production, inhibited colony formation and migration of colon cancer cells. Our studies provide preclinical rational for the further optimization of identified OX27 as a suitable lead for the possible treatment of CRC.

DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS

Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols according to formula (I) are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme.

DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS

The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1 -phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.