132868-28-1Relevant articles and documents
Metal-free, aerobic dioxygenation of alkenes using hydroxamic acids
Schmidt, Valerie A.,Alexanian, Erik J.
supporting information; experimental part, p. 4491 - 4494 (2010/08/21)
(Chemical equation presented) One dioxygenation please, hold the metal: In the presence of either oxygen or air as the sole oxidant and external oxygen atom source, a variety of unsaturated hydroxamic acids afford cyclic hydroxamates that are readily converted into 1,2-diols, with the potential for high levels of reaction stereocontrol.
Synthesis and Supramolecular Properties of Conformationally Restricted and Flexible Phospholipids
Vares, Lauri,Koulov, Atanas V.,Smith, Bradley D.
, p. 10073 - 10078 (2007/10/03)
Short synthetic routes are described to produce structurally related phospholipids that are either conformationally restricted or flexible. The conformationally restricted structures have a cyclopropyl ring in the interfacial region of the phospholipid. T
Practical catalyst for cyclic metathesis. Synthesis of functional and/or enantiopure cycloalkenes
Nugent, William A.,Feldman, Jerald,Calabrese, Joseph C.
, p. 8992 - 8998 (2007/10/02)
The oxo-tungsten complex trans-WOCl2(OAr)2 (Ar = 2,6-dibromophenyl) is prepared by reaction of WOCl4 with 2 equiv of 2,6-dibromophenol. A variety of nonconjugated dienes are cleanly cyclized to the corresponding cycloalkenes using 2 mol % of this catalyst in combination with 4 mol % of tetraethyllead. All three components of the catalyst system are commercially available. The catalytic reactions are typically complete in 1 h at 90 °C and allow the synthesis of chiral cycloalkenes with little or no loss in optical activity. For example, (R)-and (5)-citronellene have been cyclized to the corresponding (R)- or (S)-3-methylcyclopentenes in 97% enantiomeric excess. The cyclization is compatible with a variety of functional groups including some ester, amide, and ether derivatives. Tri- (but not tetra-) substituted cycloalkenes could be prepared using this catalyst.
