132870-12-3Relevant academic research and scientific papers
A novel synthesis of α-aminoaldehydes from glyoxal monoacetal
Katritzky,Borowiecka,Fan
, p. 1173 - 1176 (2007/10/02)
Primary and secondary amines condense with benzotriazole and glyoxal monoacetal to give N-substituted 1-(benzotriazolyl)-2,2-diethoxyethylamines 4, which with Grignard reagents readily yield the corresponding 2-aminoalkanal diethylacetal 5. These are easily hydrolyzed to produce α-aminoaldehydes 6.
