132874-01-2Relevant academic research and scientific papers
Heterocyclic amines having central nervous system activity
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, (2008/06/13)
Tricyclic nitrogen containing compounds, having central nervous system activity of the following structural formula: STR1 and pharmaceutically acceptable salts thereof wherein R1, R2, and R3 are independently hydrogen, C1-6 alkyl, alkenyl, or alkynyl, C3-10 cycloalkyl, or R1 and R2 are joined to form a C3-7 cyclic amine which can contain additional heteroatoms; X is hydrogen, C1-6 alkyl halogen, hydroxy, alkoxy, cyano, carboxamide, carboxyl, or carboalkoxyl; A is SO2, N, CH, CH2, CHCH3, C=O, C=S, C-SCH3, C=NH, C-NH2, C-NHCH3, C--NHCOOCH3, or C--NHCN. B is CH2, CH, C=O, N, NH or N--CH3 ; n is 0 or 1; and D is CH, CH2, C=O, O, N, NH or N--CH3. These new compounds are suitable for treating schizophrenia, Parkinson's disease, anxiety, depression or as compounds for lowering blood pressure in animal or human hosts.
Dopaminergic andSerotonergic Activities of Imidazoquinolines and Related Compounds
Moon, Malcolm W.,Morris, Jeanette K.,Heier, Richard F.,Chidester, Connie G.,Hoffmann, William E.,et al.
, p. 1076 - 1092 (2007/10/02)
The synthesis of 5-(dipropylamino)-5,6-dihydro-4H-imidazoquinolin-2(1H)-one (5), a potent dopamine D2 agonist showing high dopamine/serotonin (5HT1A) selectivity, is described.Dopaminerig activity is associated with the (R)-enantiomer
