132895-42-2

Usage

Uses

Used in Pharmaceutical Applications:
[5-(4-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanylacetic acid is used as a potential pharmaceutical agent for its diverse biological activities. [5-(4-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanylacetic acid's 1,2,4-triazole derivative nature suggests it may have antimicrobial, anticancer, and anti-inflammatory properties, making it a candidate for further research and development in the medical field.
Used in Chemical Synthesis:
[5-(4-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanylacetic acid is used as a reactive compound in chemical synthesis. The presence of the sulfanyl group may enhance its reactivity, making it a valuable precursor in the production of other chemicals or for use in various chemical reactions.
Used in Research and Development:
[5-(4-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanylacetic acid is used as a subject of research and development to better understand its properties, potential applications, and possible integration into various industries. Further analysis may reveal additional uses and benefits of {[5-(4-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid, expanding its utility and applicability in different fields.

Upstream product

• 64310-34-5 5-(4-methylphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 79-11-8 chloroacetic acid 
• 1079-82-9 1-(p-methylbenzoyl)-3-thisemicarbazide 
• 64310-34-5 3-(p-methylphenyl)-5-mercapto-4H-1,2,4-triazole 
• 3619-22-5 p-toluic hydrazide 
• 874-60-2 4-methyl-benzoyl chloride 
• 79-08-3 bromoacetic acid 
• 606952-36-7 5-benzylidene-2-(4-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one 
• 132895-43-3 2-(4-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one 

Downstream Products

• 132895-43-3 2-(4-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one 
• 132915-23-2 5-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-2-p-tolyl-thiazolo[3,2-b][1,2,4]triazol-6-one 
• 132895-44-4 6-(p-dimethylaminobenzylidene)-2-p-tolylthiazolo<3,2-b>-s-triazol-5(6H)-one 
• 606952-36-7 5-benzylidene-2-(4-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one 

Relevant academic research and scientific papers

Identification of 1,2,4-triazoles as new thymidine phosphorylase inhibitors: Future anti-tumor drugs

Thymidine phosphorylase (TP) is over expressed in several solid tumors and its inhibition can offer unique target suitable for drug discovery in cancer. A series of 1,2,4-triazoles 3a–3l has been synthesized in good yields and subsequently inhibitory potential of synthesized triazoles 3a–3l against thymidine phosphorylase enzyme was evaluated. Out of these twelve analogs five analogues 3b, 3c, 3f, 3l and 3l exhibited a good inhibitory potential against thymidine phosphorylase. Inhibitory potential in term of IC50 values were found in the range of 61.98 ± 0.43 to 273.43 ± 0.96 μM and 7-Deazaxanthine was taken as a standard inhibitor with IC50 = 38.68 ± 4.42 μM. Encouraged by these results, more analogues 1,2,4-triazole-3-mercaptocarboxylic acids 4a–4g were synthesized and their inhibitory potential against thymidine phosphorylase was evaluated. In this series, six analogues 4b–4g exhibited a good inhibitory potential in the range of 43.86 ± 1.11–163.43 ± 2.03 μM. Angiogenic response of 1,2,4-triazole acid 4d was estimated using the chick chorionic allantoic membrane (CAM) assay. In the light of these findings, structure activity relationship and molecular docking studies of selected triazoles to determine the key binding interactions was discussed. Docking studies demonstrate that synthesized analogues interacted with active site residues of thymidine phosphorylase enzyme through π-π stacking, thiolate and hydrogen bonding interactions.

Structure of reaction products of substituted [1,3]thiazolo[3,2-b][1,2,4] triazol-6(5H)-ones with amines and hydrazines

Reactions of 2-(4-methylphenyl)[1,3]triazolo[3,2-b][1,2,4]thiazol-6(5H)-one and 5-benzylidene-2-(4- methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)- one with amines and hydrazines of diverse structures were studied. The structure of the reaction pro

Condensation of 5-(4-methylphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione with haloacetic acids

Reactions of triazolethiones with haloacetic acids were studied with 5-(4-methylphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione as an example. It was proved for the first time by X-ray diffraction that the cyclocondensation of these compounds proceeds regiospecifically to give 2-(4-methylphenyl)[1,3] thiazolo[3,2-b][1,2,4]triazol-6(5H)-one rather than its isomer 3-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-5(6H)-one.