13290-19-2Relevant academic research and scientific papers
Melanoma-targeted delivery system (part 1): Design, synthesis and evaluation of releasable disulfide drug by glutathione
El Aissi, Radhia,Chezal, Jean-Michel,Tarrit, Sébastien,Chavignon, Olivier,Moreau, Emmanuel
, p. 668 - 680 (2015)
Abstract Here we describe the design and synthesis of a prodrug developed for pigmented melanoma therapy, consisting of a Melanin-Targeting Probe (MTP) conjugated to 5-iodo-2′-deoxyuridine (IUdR) with a reduction-sensitive pre-determined breaking point. C
A protective group for indolecarboxylic group, and nucleic acid synthesis method for automatic composing nucleic acid and Amidide
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Paragraph 0062; 0063; 0064, (2019/05/10)
PROBLEM TO BE SOLVED: To provide a protecting group for indole group, and an amidide for automatic nucleic acid synthesis which can produce a nucleic acid stably and a precursor thereof, and a nucleic acid synthesis method.SOLUTION: Disclosed is an amidid
Synthesis and evaluation of sulfonylethyl-containing phosphotriesters of 3′-azido-3′-deoxythymidine as anticancer prodrugs
Wang, Jiang,Wang, Yi-Jun,Chen, Zhe-Sheng,Kwon, Chul-Hoon
, p. 5747 - 5756 (2015/01/09)
A series of bis(sulfonylethyl) and mono(sulfonylethyl) phenyl phosphotriesters of zidovudine (3′-azido-3′-deoxythymidine, AZT) were synthesized as potential anticancer prodrugs that liberate AZT monophosphate via nonenzymatic β-elimination mechanism. Stab
One-pot catalyst-free synthesis of β-and γ-hydroxy sulfides using diaryliodonium salts and microwave irradiation
Vaddula, Buchi Reddy,Varma, Rajender S.,Leazer, John
supporting information, p. 6852 - 6855 (2013/02/22)
A simple and rapid one-pot protocol is described for the preparation of α- and β-hydroxy sulfides. The direct solvent-free microwave irradiation of diaryliodonium salts, potassium thiocyanate, and ethylene glycol/β-propylene glycol without any catalyst or base affords the final compounds in good yields (65-95 %) in around 10-25 min. Copyright
THIOL SULFONE METALLOPROTEASE INHIBITORS
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, (2008/06/13)
This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfone inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes for the preparation of proteinase inhibitors and processes for treating pathological conditions associated with pathological matrix metalloproteinase activity related to MMP-13.
THIOL SULFONE METALLOPROTEASE INHIBITORS
-
, (2008/06/13)
This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfone inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes for the preparation of proteinase inhibitors and processes for treating pathological conditions associated with pathological matrix metalloproteinase activity related to MMP-13.
