13290-48-7

Basic information

• Product Name: 1-(3-Methylbenzoyl)piperidine
• Synonyms: 1-(3-Methylbenzoyl)piperidine;3-Methylphenyl(piperidino) ketone
• CAS NO: 13290-48-7
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.2802
• Mol File: 13290-48-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 350.4°Cat760mmHg
• Flash Point: 160.5°C
• Appearance: /
• Density: 1.065g/cm³
• Vapor Pressure: 4.41E-05mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: 1-(3-Methylbenzoyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Methylbenzoyl)piperidine(13290-48-7)
• EPA Substance Registry System: 1-(3-Methylbenzoyl)piperidine(13290-48-7)

Safety Data

• Hazardous Substances Data: 13290-48-7(Hazardous Substances Data)

Usage

Description

1-(3-Methylbenzoyl)piperidine is a chemical compound characterized by the molecular formula C16H19NO. It is a derivative of piperidine, featuring a methylbenzoyl group attached to the piperidine ring. 1-(3-Methylbenzoyl)piperidine is predominantly utilized in the realms of medicinal chemistry and pharmaceutical research, where it holds promise for the development of novel drugs and therapeutic agents. Although its specific biological and pharmacological properties are still under investigation, it is hypothesized to possess potential as a psychoactive and analgesic agent. Further research is essential to comprehensively understand and harness the properties and potential applications of 1-(3-Methylbenzoyl)piperidine.

Uses

Used in Pharmaceutical Research:
1-(3-Methylbenzoyl)piperidine is used as a key compound in pharmaceutical research for the development of new drugs and therapeutic agents. Its unique structure and potential biological activities make it a valuable candidate for creating innovative medications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(3-Methylbenzoyl)piperidine is employed as a building block for designing and synthesizing new molecules with potential medicinal properties. Its structural versatility allows for the creation of a wide range of compounds with diverse pharmacological effects.
Used in Psychoactive Agent Development:
1-(3-Methylbenzoyl)piperidine is used as a potential psychoactive agent due to its structural similarities with known psychoactive compounds. Its effects on the central nervous system are yet to be fully explored, but it holds promise for the development of new treatments for various psychiatric and neurological disorders.
Used in Analgesic Agent Development:
As a potential analgesic agent, 1-(3-Methylbenzoyl)piperidine is investigated for its ability to alleviate pain. Its specific mechanism of action and efficacy in pain management are areas that require further research and development.

InChI:InChI=1/C13H17NO/c1-11-6-5-7-12(10-11)13(15)14-8-3-2-4-9-14/h5-7,10H,2-4,8-9H2,1H3

Upstream product

• 110-89-4 piperidine 
• 313549-89-2 (1H-benzo-[d][1,2,3]triazol-1-yl)(m-tolyl)methanone 
• 587-03-1 3-methylbenzyl alcohol 
• 1711-06-4 3-Methylbenzoyl chloride 
• 620-23-5 m-tolyl aldehyde 
• 36718-84-0 4-nitrophenyl 3-methylbenzoate 

Downstream Products

• 672295-87-3 3-(piperidine-1-carbonyl)-benzaldehyde 

Relevant articles and documents

An efficient method for the preparation of styrene derivatives via Rh(III)-catalyzed direct C-H vinylation

The development of a method for the Rh(III)-catalyzed direct vinylation of an aromatic C-H bond to give functionalized styrenes in good yield, using vinyl acetate as a convenient and inexpensive vinyl source, is reported. High functional group tolerance is demonstrated for electronically distinct arenes as well as different directing groups. Mechanistic investigation resulted in the characterization of a novel rhodium-metallacycle, which represents the first X-ray structure of a [1,2]-Rh(III)-alkenyl addition adduct.

METHODS OF CONTROLLING CROP PESTS USING AROMATIC AMIDE INSECT REPELLENTS, METHODS OF MAKING AROMATIC AMIDE INSECT REPELLENTS, AND NOVEL AROMATIC AMIDE INSECT REPELLENTS

Methods of protecting fruit crops from flying insect pests and of repelling flying insects using aromatic amide compounds are disclosed. The methods apply the compounds to various surfaces, such as the fruit crops, the ground or structures adjacent to the fruit crops, or an object, article, human skin or animal. The compounds have the formula RxC6Hy—C(═O)—N(Cy), where RxC6Hy is a substituted phenyl group, each R group is independently C1-C6 alkyl, substituted C1-C4 alkyl, (substituted) C6-C10 aryl, C1-C4 alkoxy, C6-C10 aryloxy, halogen, nitro, cyano, cyanate, isocyanate, nitroso, C1-C4 alkylthio, phenylthio, (halogen-substituted) C1-C4 alkylsulfonyl, phenylsulfonyl, tolylsulfonyl, amino, mono- or di-C1-C4 alkylamino, diphenylamino, di-C1-C4 alkylamido, formyl, C2-C7 acyl, or C1-C6 alkoxycarbonyl; x is an integer of 1 to 5; x+y=5; Cy is a C2-C8 (substituted) alkadiyl, a C4-C6 (substituted) alkenediyl, or a (substituted) diyl of the formula —(CH2CH2)—O—(CH2CH2)—, —(CH2CH2)—NR′—(CH2CH2)— or —(CH2CH2)—S—(CH2CH2)— that, along with the amide N atom, forms a non-aromatic cyclic group; and R′ is C1-C6 alkyl, substituted C1-C4 alkyl, (substituted) C6-C10 aryl, or (substituted) benzyl.

Copper-Catalyzed Aerobic Oxidative Amidation of Benzyl Alcohols

A Cu-catalyzed synthesis of amides from alcohols and secondary amines using the oxygen in air as the terminal oxidant has been developed. The methodology is operationally simple requiring no high pressure equipment or handling of pure oxygen. The commercially available, nonprecious metal catalyst, Cu(phen)Cl2, in conjunction with di-tert-butyl hydrazine dicarboxylate and an inorganic base provides a variety of benzamides in moderate to excellent yields. The pKa of amine conjugate acid and electronics of alcohol were shown to impact the selection of base for optimal reactivity. A mechanism consistent with the observed reactivity trends, KIE, and Hammett study is proposed.