1329166-85-9

Usage

Uses

Used in Agricultural Industry:
(E)-3-(5-chloro-2-(difluoromethoxy)phenyl)acrylic acid is used as a herbicide for controlling a broad spectrum of annual and perennial grasses and broadleaf weeds. Its application reason is due to its ability to inhibit the enzyme acetolactate synthase, which is essential for amino acid synthesis in plants, thereby disrupting their growth and leading to weed control.
Used in Non-Agricultural Settings:
In addition to its agricultural applications, (E)-3-(5-chloro-2-(difluoromethoxy)phenyl)acrylic acid is also used in non-agricultural settings for weed control. Its application reason in this context is similar to its agricultural use, as it effectively targets and controls unwanted vegetation in areas such as gardens, lawns, and other non-crop environments.
Safety and Handling:

Upstream product

• 145742-68-3 5-chloro-2-(difluoromethoxy)benzaldehyde 
• 1329166-86-0 (E)-tert-butyl 3-(5-chloro-2-(difluoromethoxy)phenyl)acrylate 

Relevant academic research and scientific papers

SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.

SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I) or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.

SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.

MACROCYCLES AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.