13292-45-0 Usage
Description
N-Demethyl Rifampin, also known as a metabolite of Rifampicin (R508000), is a dark red solid with unique chemical properties. It is derived from the parent compound Rifampicin, which is an antibiotic used to treat various bacterial infections. The transformation from Rifampicin to N-Demethyl Rifampin occurs through metabolic processes, resulting in a compound with distinct characteristics and potential applications.
Uses
Used in Pharmaceutical Industry:
N-Demethyl Rifampin is used as an active metabolite for enhancing the efficacy of Rifampicin in treating bacterial infections. As a metabolite, it may exhibit improved pharmacokinetic properties, such as increased bioavailability and reduced toxicity, compared to the parent compound. This can lead to more effective treatment outcomes and potentially lower doses required for therapeutic effects.
Used in Research and Development:
In the field of research and development, N-Demethyl Rifampin serves as a valuable compound for studying the metabolic pathways of Rifampicin and understanding its interactions with various biological systems. This knowledge can be applied to optimize the drug's efficacy, develop new drug formulations, and identify potential drug-drug interactions.
Used in Drug Metabolism Studies:
N-Demethyl Rifampin is used as a key compound in drug metabolism studies, providing insights into the metabolic processes and enzyme interactions involved in the conversion of Rifampicin to its active metabolite. This information can be crucial for the development of new drugs with improved metabolic profiles and reduced side effects.
Used in Quality Control and Standardization:
In the pharmaceutical industry, N-Demethyl Rifampin is used as a reference compound for quality control and standardization of Rifampicin-containing products. By comparing the properties and concentrations of N-Demethyl Rifampin in different formulations, manufacturers can ensure the consistency, purity, and potency of their products, ultimately contributing to patient safety and effective treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 13292-45-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,2,9 and 2 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 13292-45:
(7*1)+(6*3)+(5*2)+(4*9)+(3*2)+(2*4)+(1*5)=90
90 % 10 = 0
So 13292-45-0 is a valid CAS Registry Number.
InChI:InChI=1/C42H56N4O12/c1-20-11-10-12-21(2)41(54)45-32-27(19-44-46-16-14-43-15-17-46)36(51)29-30(37(32)52)35(50)25(6)39-31(29)40(53)42(8,58-39)56-18-13-28(55-9)22(3)38(57-26(7)47)24(5)34(49)23(4)33(20)48/h10-13,18-20,22-24,28,33-34,38,43-44,48-50,52H,14-17H2,1-9H3,(H,45,54)/b11-10+,18-13+,21-12+,27-19+/t20-,22+,23+,24+,28-,33-,34+,38?,42-/m0/s1
13292-45-0Relevant articles and documents
Radiosynthesis and bioimaging of the tuberculosis chemotherapeutics isoniazid, rifampicin and pyrazinamide in baboons
Liu, Li,Xu, Youwen,Shea, Colleen,Fowler, Joanna S.,Hooker, Jacob M.,Tonge, Peter J.
, p. 2882 - 2891 (2010)
The front-line tuberculosis (TB) chemotherapeutics isoniazid (INH), rifampicin (RIF), and pyrazinamide (PZA) have been labeled with carbon-11 and the biodistribution of each labeled drug has been determined in baboons using positron emission tomography (P
