1329423-64-4Relevant academic research and scientific papers
Efficient syntheses of new chromone- And chromanequinoline hybrids and their aza-analogs
Bouraioua, Abelmalek,Berreeb, Fabienne,Bouacidac, Sofiane,Carbonib, Bertrand,Debachea, Abdelmadjid,Royneld, Thierry,Belfaitah, Ali
scheme or table, p. 374 - 379 (2012/05/04)
Some novel chromone- and chromanequinoline hybrids and their aza-analogs were synthesized from 2-chloro-3-quinolinecarboxaldehydes as starting materials. The cyclization of 2-hydroxychalcones in the presence of AcONa yielded chroman-4-ones, while, in the typical AFO conditions, the 2-corresponding quinolyl-3-hydroxyflavonols were obtained. These approaches were extended to 2-aminochalcones, which delivered the 3-hydroxy-2,3-dihydroquinolin- 4(1H)-one via an epoxy-ketone and 2-quinolyl-2,3-dihydroquinoline-4(1H)-one under microwave irradiation in the presence of silica gel impregnated with indium (III) chloride.
