1329426-63-2

Basic information

• Product Name: C₃₃H₄₈Cl₃NO₂₁
• Synonyms: C₃₃H₄₈Cl₃NO₂₁
• CAS NO: 1329426-63-2
• Molecular Weight: 901.097
• Mol File: 1329426-63-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₃₃H₄₈Cl₃NO₂₁(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₃H₄₈Cl₃NO₂₁(1329426-63-2)
• EPA Substance Registry System: C₃₃H₄₈Cl₃NO₂₁(1329426-63-2)

Safety Data

• Hazardous Substances Data: 1329426-63-2(Hazardous Substances Data)

Upstream product

• 1445783-71-0 C₇₆H₆₀Cl₉NO₂₃ 
• 86520-63-0 2,3,4,6-tetra-O-acetyl-α-galactopyranosyl trichloroacetimidate 
• 1329426-59-6 C₈₇H₇₉Cl₈NO₃₃ 

Downstream Products

• 86594-19-6 lacto-N-neo-tetraose 
• 68124-21-0 C₃₁H₄₉NO₂₀ 
• 68124-22-1 1-O-benzyl-β-lacto-N-neotetraose 

Relevant articles and documents

Method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt) containing N-acetyllactosamine

The present invention relates to a method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt, formula (I)) especially in large scale, as well as intermediates in the synthesis, a new crystal form (polymorph) of LNnt, and the use thereof in pharmaceutical or nutritional compositions.

SYNTHESIS OF NEW FUCOSE-CONTAINING CARBOHYDRATE DERIVATIVES

A method for the synthesis of a compound of formula (1) or a salt thereof, wherein A is a carbohydrate linker which is a lactosyl moiety or which consists of a lactosyl moiety and at least one monosaccharide unit selected from the group consisting of: glucose, galactose, N-acetylglucosamine, fucose and N-acetyl neuraminic acid; and wherein R1 is one of the following anomeric protecting groups: a) -OR2, wherein R2 is a protecting group removable by catalytic hydrogenolysis; b) -SR3, wherein R3 is an optionally substituted alkyl, an optionally substituted aryl or an optionally substituted benzyl; c) -NH- C(R")=C(R')2, wherein each R' independently is one of the following electron withdrawing groups: -CN, -COOH, -COO-alkyl, -CO-alkyl, -CONH2, -CONH- alkyl or -CON(alkyl)2, or wherein the two R'-groups are linked together and form -CO-(CH2)2-4-CO- and thus form, together with the carbon atom to which they are attached, a 5-7 membered cycloalkan-1,3-dione, in which dione any of the methylene groups is optionally substituted with 1 or 2 alkyl groups, and R" is H or alkyl, in which a fucosyl donor of formula (2) wherein X is selected from the group consisting of: a guanosine diphosphatyl moiety, a lactose moiety, azide, fluoride, optionally substituted phenoxy-, optionally substituted pyridinyloxy-, optionally substituted 3-oxo-furanyloxy- of formula (A), optionally substituted 1,3,5-triazinyloxy- of formula (B), 4-methylumbelliferyloxy-group of formula (C), and a group of formula (D) wherein Ra is independently H or alkyl, or two vicinal Ra groups represent a =C(Rb)2 group, wherein Rb is independently H or alkyl, Rc is independently selected from the group consisting of alkoxy, amino, alkylamino and dialkylamino, Rd is selected from the group consisting of H, alkyl and -C(=O)Re, wherein Re is OH, alkoxy, amino, alkylamino, dialkylamino, hydrazino, alkylhydrazino, dialkylhydrazino or trialkylhydrazino, is reacted with an acceptor of formula H-A-R1 or a salt thereof, wherein A and R1 are as defined above, under the catalysis of an enzyme capable of transferring fucose. A compound of formula 1', its use in manufacture of human milk oligosaccharides, a method of manufacture of human milk oligosaccharides, and a fucosyl donor are also provided.