1329438-79-0

Upstream product

• 1329438-77-8 1,1'-(3-methyl-4-phenylthieno[2,3-b]thiophene-2,5-diyl)diethanone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1412911-01-3 1,1'-(3-methyl-4-phenylthieno[2,3-b]thiophene-2,5-diyl)bis(3-(hydroxyamino)prop-2-en-1-one) 
• 1412911-02-4 3-(dimethylamino)-1-(5-(6-(5-((E)-3-(dimethylamino)acryloyl)-3-methyl-4-phenylthieno[2,3-b]thiophen-2-yl)nicotinoyl)-3-methyl-4-phenylthieno[2,3-b]thiophen-2-yl)prop-2-en-1-one 
• 1412911-00-2 (2E,2'E)-1,1'-(3-methyl-4-phenylthieno[2,3-b]thiophene-2,5-diyl)bis(4,4,4-triethoxybut-2-en-1-one) 

Relevant academic research and scientific papers

Expeditious and highly efficient protocol for the synthesis of novel diversely substituted thieno[2,3-b]thiophene

1,1′-(3-Methyl-4-phenylthieno[2,3-b]thiophene-2,5-diyl)bis(4,4,4 triethoxybut-2-en-1-one)-3 has been reported by one-pot reaction of enaminone derivative 2 with triethylorthoformate in fairly high yields. The hitherto unknown bis-hydroxyl amine derivatives 4 via N-nucleophile under basic conditions is described. Additionally, the novel Compound 5 were synthesized by the cyclization of enaminone derivative 2 using AcOH with the aid of catalytic amount of AcONH4. Nevertheless, facile reaction sequences for the preparation of 6, 7, 8a-c, and 9a-c starting with 1,1′-(3-methyl-4- phenylthieno[2,3-b]thiophene-2,5-diyl)diethanone 1 have been developed. Finally, several bis-heterocycles 10a-f were synthesized through a stepwise formation of hydrazone followed by a Michael 1,4-addition of the nucleophile nitrogen atom and provides a convenient access to an important class of nitrogen heterocycles.