132945-96-1

Usage

Molecular structure

1-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methyl-, 1,1-dimethylethyl ester is an ester of 1-Pyrrolidinecarboxylic acid with a 1,1-dimethylethyl group and a 2-methyl group attached.

Functional groups

The compound contains an ester group, a carboxylic acid moiety, and a dimethylsilyl group.

Stereochemistry

The compound has a (2R,4R)configuration, indicating the arrangement of the chiral centers in the molecule.

Potential applications

This chemical may have various industrial or research applications due to its specific structure and properties.

Handling precautions

The compound should be handled and used with caution due to its complexity and potential reactivity.

Upstream product

• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 

Downstream Products

• 114676-93-6 (2R,4R)-tert-butyl 4-hydroxy-2-methylpyrrolidine-1-carboxylate 
• 213699-35-5 (3R,5R)-3-benzoyloxy-1-(tert-butoxycarbonyl)-5-methyl-2-pyrrolidinone 
• 213699-39-9 (2R,3R,5R)-3-benzoyloxy-2-cyano-1-methoxycarbonyl-5-methylpyrrolidine 
• 213699-40-2 (2S,3R,5R)-3-benzoyloxy-2-cyano-1-methoxycarbonyl-5-methylpyrrolidine 
• 213699-37-7 (3R,5R)-3-benzoyloxy-1-methoxycarbonyl-5-methyl-2-pyrrolidinone 
• 213699-36-6 (3R,5R)-3-benzoyloxy-5-methyl-2-pyrrolidinone 
• 114717-08-7 (2R,3R,5R)-3-hydroxy-5-methylproline 
• 114717-06-5 (2S,3R,5R)-3-hydroxy-5-methyl-2-pyrrolidinecarboxylic acid 
• 859213-36-8 (2R,4R)-tert-butyl 2-methyl-4-(tosyloxy)pyrrolidine-1-carboxylate 
• 348165-62-8 (2R,4S)-tert-butyl 4-hydroxy-2-methylpyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

Design, synthesis, and antileukemic activity of stereochemically defined constrained analogues of FTY720 (Gilenya)

FTY720 functions as an immunosuppressant due to its effect on sphingosine-1-phosphate receptors. At doses well above those needed for immunosuppression, FTY720 also has antineoplastic actions. Our published work suggests that at least some of FTY720's anticancer activity is independent of its effects on S1P receptors and due instead to its ability to induce nutrient transporter down-regulation. Compounds that trigger nutrient transporter loss but lack FTY720's S1P receptor-related, dose-limiting toxicity have the potential to be effective and selective antitumor agents. In this study, a series of enantiomerically pure and stereochemically diverse O-substituted benzyl ethers of pyrrolidines was generated and tested for the ability to kill human leukemia cells. The stereochemistry of the hydroxymethyl was found to be a key determinant of compound activity. Moreover, phosphorylation of this group was not required for antileukemic activity.

A METHOD OF TREATING LIVER FIBROSIS

The present invention relates to a method of treating hepatis C and/or liver fibroisis with 3-cycloalkylaminopyrrolidine derivatives of the present invention