1329451-08-2Relevant academic research and scientific papers
Asymmetric vinylogous Mannich reactions: A versatile approach to functionalized heterocycles
Ruan, Shu-Tang,Luo, Jie-Min,Du, Yu,Huang, Pei-Qiang
, p. 4938 - 4941 (2011/11/06)
Asymmetric vinylogous Mannich reaction (VMR) of 2-(tert- butyldimethylsilyloxy)furan (TBSOF, 1) with (RS)- or (S S)-t-BS-imines (3) furnished 5-aminoalkylbutenolides 7a-k in 75-87% yields with anti/syn ratios ranging from 75:25 to 97:3. Butenolides 7a-f,k were readily converted into substituted lactones 8 and 5 and 6-substituted 5-hydroxypiperidin-2-ones 11a-g, which are, in turn, key intermediates for the synthesis of many bioactive compounds.
