132951-65-6

Basic information

• Product Name: 2-Naphthalenemethanamine, 6-methoxy-a-methyl-, (aR)-
• Synonyms: 2-Naphthalenemethanamine, 6-methoxy-a-methyl-, (aR)-;2-Naphthalenemethanamine, 6-methoxy-α-methyl-, (αR)-;2-NaphthaleneMethanaMine;6-Methoxy-a-Methyl-;(1R)-1-(6-METHOXY(2-NAPHTHYL))ETHYLAMINE;(1R)-1-(6-methoxynaphthalen-2-yl)ethanamine
• CAS NO: 132951-65-6
• Molecular Formula: C₁₃H₁₅NO
• Molecular Weight: 201.268
• Product Categories: API intermediates
• Mol File: 132951-65-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Naphthalenemethanamine, 6-methoxy-a-methyl-, (aR)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Naphthalenemethanamine, 6-methoxy-a-methyl-, (aR)-(132951-65-6)
• EPA Substance Registry System: 2-Naphthalenemethanamine, 6-methoxy-a-methyl-, (aR)-(132951-65-6)

Safety Data

• Hazardous Substances Data: 132951-65-6(Hazardous Substances Data)

Usage

General Description

2-Naphthalenemethanamine, 6-methoxy-a-methyl-, (aR)- is a chemical compound with the molecular formula C12H15NO. It is a chiral compound, which means it has a three-dimensional structure with a specific orientation. The compound has a naphthalene ring and an amine group, as well as a methoxy and a methyl group. It is commonly used as an intermediate in organic synthesis and in the pharmaceutical industry. The (aR)- designation in its name indicates that it is the enantiomer with the R configuration at the chiral center. 2-Naphthalenemethanamine, 6-methoxy-a-methyl-, (aR)- has various potential applications in drug development and other scientific research.

Upstream product

• 133097-30-0 <1-(6-Methoxy-2-naphthyl)ethyl>amin 
• 132980-26-8 <1-(6-Methoxy-2-naphthyl)ethyl>ammonium-tartrat 

Relevant articles and documents

Synthesis of enantiopure 6-methoxy-2-naphthylglycolic acid and its application as a resolving agent

6-Methoxy-2-naphthylglycolic acid (6-MNGA) was designed as a novel acidic resolving agent, on the model of 2-naphthylglycolic acid (2-NGA). Enantiopure 6-MNGA was easily obtained from commercially available 2-bromo-6- methoxynaphthalene through four steps and was found to show a better chiral recognition ability for racemic 1-arylethylamines than the prototype 2-NGA did. The X-ray crystallographic analyses of less-soluble diastereomeric salts revealed that the introduction of a methoxy group at the 6-position of the 2-NGA skeleton made CH/π interaction(s) effective between 6-MNGA molecules and also between the 6-MNGA molecule and the target amine molecule. The methoxy group was also found to contribute to the realization of effective van der Waals interaction. These interactions played important roles for the stabilization of the less-soluble diastereomeric salts to improve the chiral recognition ability of 6-MNGA, compared to that of 2-NGA.