1329520-42-4

Basic information

• Product Name: S-(6,11-dioxo-6,11-dihydro-1H-anthra[1,2-d]imidazol-2-yl) 2,5-bis(trifluoromethyl)benzothioate
• Synonyms: S-(6,11-dioxo-6,11-dihydro-1H-anthra[1,2-d]imidazol-2-yl) 2,5-bis(trifluoromethyl)benzothioate
• CAS NO: 1329520-42-4
• Molecular Weight: 520.411
• Mol File: 1329520-42-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: S-(6,11-dioxo-6,11-dihydro-1H-anthra[1,2-d]imidazol-2-yl) 2,5-bis(trifluoromethyl)benzothioate(CAS DataBase Reference)
• NIST Chemistry Reference: S-(6,11-dioxo-6,11-dihydro-1H-anthra[1,2-d]imidazol-2-yl) 2,5-bis(trifluoromethyl)benzothioate(1329520-42-4)
• EPA Substance Registry System: S-(6,11-dioxo-6,11-dihydro-1H-anthra[1,2-d]imidazol-2-yl) 2,5-bis(trifluoromethyl)benzothioate(1329520-42-4)

Safety Data

• Hazardous Substances Data: 1329520-42-4(Hazardous Substances Data)

Upstream product

• 1758-68-5 1,2-diamino-9,10-anthraquinone 
• 1190059-19-8 2-mercapto-1⁽³⁾H-anthra[1,2-d]imidazole-6,11-dione 
• 393-82-8 2,5-bis(trifluoromethyl)benzoyl chloride 

Relevant articles and documents

Structure-based design, synthesis and biological evaluation of novel anthra[1,2-d]imidazole-6,11-dione homologues as potential antitumor agents

By using fragment-based design strategies, a series of 2-thio-substituted anthra[1,2-d]imidazole-6,11-diones were synthesized and evaluated for hTERT repressing activities, cell proliferations, and NCI 60-cell panel assay. Compounds 2, 3, 4, 11, 15 and 35 were selected by the NCI and 3, 4, 11 and 15 represent the GI50, TGI and LC50, respectively. Among them, all were moderate selectivity toward leukemia cancer except for 4 exhibited distinctive selectivity of CNS and renal cancer with 7.403 and 6.475. The overall of test compounds exhibited different cytostatic and cytotoxic activities for further developing potential application as anticancer drugs.