A 71915, also known as 2-(4-(2-hydroxyethoxy)-3,5-dimethoxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one, is a chemical compound that serves as a selective inhibitor of the tyrosine kinase activity of vascular endothelial growth factor receptor-2 (VEGFR2). It is recognized for its potential in cancer research and targeted therapy development, particularly against VEGFR2-driven malignancies.
132956-87-7
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Basic information
- Product Name: A 71915
- Synonyms: A 71915;(Arg6,b-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) aMide (Mouse, rabbit, rat);H-Arg-Cys-b-cyclohexyl-Ala-Gly-Gly-Arg-Ile-Asp-Arg-Ile-D-Tic-Arg-Cys-NH2
- CAS NO:132956-87-7
- Molecular Formula: C69H117N25O16S2
- Molecular Weight: 1616.97
- EINECS: N/A
- Product Categories: N/A
- Mol File: 132956-87-7.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: A 71915(CAS DataBase Reference)
- NIST Chemistry Reference: A 71915(132956-87-7)
- EPA Substance Registry System: A 71915(132956-87-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 132956-87-7(Hazardous Substances Data)
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132956-87-7 Usage
Uses
Used in Cancer Research:A 71915 is used as a research tool for studying the VEGFR2 pathway, which is crucial in tumor angiogenesis and progression. Its selective inhibition of VEGFR2 tyrosine kinase activity makes it a valuable asset in understanding the mechanisms of cancer growth and metastasis.
Used in Anti-angiogenic Therapy:
A 71915 is used as an anti-angiogenic agent to inhibit the formation of new blood vessels that supply nutrients to tumors, thereby limiting their growth and spread. Its inhibitory effects on the proliferation and migration of endothelial cells contribute to its potential as a therapeutic agent in anti-angiogenic treatments.
Used in Targeted Therapies:
A 71915 is used as a targeted therapy agent for the treatment of various types of cancer that are driven by the VEGFR2 pathway. By specifically targeting this pathway, A 71915 has shown promise in the development of more effective and less toxic cancer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 132956-87-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,9,5 and 6 respectively; the second part has 2 digits, 8 and 7 respectively.Calculate Digit Verification of CAS Registry Number 132956-87:
(8*1)+(7*3)+(6*2)+(5*9)+(4*5)+(3*6)+(2*8)+(1*7)=147
147 % 10 = 7
So 132956-87-7 is a valid CAS Registry Number.
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A 71915
