1329600-87-4Relevant academic research and scientific papers
Solid-phase parallel synthesis of a tetrahydroindazolone library containing three unique core skeletons
Kim, Jonghoon,Song, Heebum,Park, Seung Bum
, p. 2062 - 2072 (2011)
We have developed a practical strategy for the regioselective synthesis of a 1-(hetero)aryl-3-substituted tetrahydroindazolone library. The condensation of in situ generated arylhydrazine on solid supports with 2-acylcyclohexane-1,3- diones ensured the efficiency of solid-phase parallel synthesis. In addition, we introduced three unique core skeletons containing nitrophenyl, anilyl, and pyridyl groups to maximize the molecular diversity through a diverse display of polar surface area in 3D chemical space. A 162-membered drug-like tetrahydroindazolone library was constructed in an average purity of 92 % without further purification.
