132961-05-8

Basic information

• Product Name: 3-[2-[4-[(Z)-(2,4-Difluorophenyl)(hydroxyiMino)Methyl]-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-Methyl-4H-pyrido[1,2-a]pyriMidin-4-one
• Synonyms: 3-[2-[4-[(Z)-(2,4-Difluorophenyl)(hydroxyiMino)Methyl]-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-Methyl-4H-pyrido[1,2-a]pyriMidin-4-one;Risperidone Z-OxiMe IMpurity;Risperidone IMpurity B;Risperidone EP IMpurity B;3-[2-[4-[(Z)-(2,4-difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one;(Z)-3-(2-(4-((2,4-difluorophenyl)(hydroxyimino)methyl)piperidin-1-yl)ethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
• CAS NO: 132961-05-8
• Molecular Formula: C₂₃H₂₈F₂N₄O₂
• Molecular Weight: 430.4908264
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 132961-05-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 568.998°C at 760 mmHg
• Flash Point: 297.919°C
• Appearance: /
• Density: 1.349g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.631
• PKA: 11.20±0.28(Predicted)
• CAS DataBase Reference: 3-[2-[4-[(Z)-(2,4-Difluorophenyl)(hydroxyiMino)Methyl]-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-Methyl-4H-pyrido[1,2-a]pyriMidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-[4-[(Z)-(2,4-Difluorophenyl)(hydroxyiMino)Methyl]-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-Methyl-4H-pyrido[1,2-a]pyriMidin-4-one(132961-05-8)
• EPA Substance Registry System: 3-[2-[4-[(Z)-(2,4-Difluorophenyl)(hydroxyiMino)Methyl]-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-Methyl-4H-pyrido[1,2-a]pyriMidin-4-one(132961-05-8)

Safety Data

• Hazardous Substances Data: 132961-05-8(Hazardous Substances Data)

Usage

Uses

Risperidone Z-Oxime is an impurity of Risperidone (R525000). Risperidone impurity per USP.

InChI:InChI=1/C23H28F2N4O2/c1-15-18(23(30)29-10-3-2-4-21(29)26-15)9-13-28-11-7-16(8-12-28)22(27-31)19-6-5-17(24)14-20(19)25/h5-6,14,16,31H,2-4,7-13H2,1H3/b27-22-

Upstream product

• 93076-03-0 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride 
• 691007-05-3 C₁₂H₁₄F₂N₂O 

Downstream Products

• 106266-06-2 Risperidone 

Relevant articles and documents

Process for making risperidone and intermediates therefor

The formation of risperidone is enhanced by the use of enriched Z-isomer oxime intermediate(s) of formula (3) or (7). The oxime(s) can be isomerically enriched by a variety of techniques including the use of the novel acetic acid salt thereof, which affords, inter alia, resolution of the isomers and/or by heat conversion.