1329675-16-2Relevant academic research and scientific papers
Stereoselective total synthesis of umuravumbolide
Shekhar, Vanam,Reddy, Dorigondla Kumar,Reddy, Sudina Purushotham,Prabhakar, Peddikotla,Venkateswarlu, Yenamandra
, p. 4460 - 4464 (2011/10/12)
A simple and efficient stereoselective total synthesis of desacetylumuravumbolide (1a) and umuravumbolide (1b), starting from commercially available valeraldehyde has been described. The synthetic strategy involves a highly enantioselective zinc-mediated addition of protected 2 alkyn-1-ol to aldehyde, a Crimmins aldol reaction, and Horner-Wadsworth-Emmons olefination as key steps. A simple and efficient stereoselective total synthesis of umuravumbolide and desacetylumuravumbolide starting from commercially available valeraldehyde is described. The synthetic strategy involves a highly enantioselective zinc-mediated addition, a Crimmins aldol reaction, and Horner-Wadsworth-Emmons olefination as key steps.
