1329694-84-9Relevant academic research and scientific papers
First synthesis of α,β-unsaturated lactones with high diversity through the Passerini reaction and ring-closing metathesis (RCM)
Schwaeblein, Almuth,Martens, Juergen
, p. 4335 - 4344 (2011/09/15)
A new class of α,β-unsaturated pyran-2-carboxamides was easily accessed by a multicomponent reaction (MCR), followed by a ring-closing metathesis (RCM) using a ruthenium catalyst. In the first step, α-acyloxy carboxamides with two terminal double bonds were formed from terminal unsaturated carboxylic acids, allyl ketones, and isocyanides (Passerini reaction, P-3CR). A new class of α,β-unsaturated pyran-2-carboxamides was easily accessed by amulticomponent reaction (MCR), followedby a ring-closing metathesis (RCM) using a ruthenium catalyst.
