132970-99-1Relevant articles and documents
PEA-SEEDLING DIAMINE OXIDASE: APPLICATIONS IN SYNTHESIS AND EVIDENCE RELATING TO ITS MECHANISM OF ACTION
Cragg, John E.,Herbert, Richard B.,Kgaphola, Mashupye M.
, p. 6907 - 6910 (2007/10/02)
Diamines (6)-(8) and (11) act as acceptable substrates for diamine oxidase (DAO) and the novel phenacyl derivatives (2) are obtained in satisfactory preparative yield; no enantioselectivity is observed with (11) as an enzyme substrate.Remarkably, the triamines (9) and (13) are not oxidized and, moreover, (9) acts as a notable inhibitor for the DAO catalysed oxidation of (4) and (5).Kinetic evidence relevant to the mechanism of DAO action is presented, and is discussed in terms of a model for DAO-catalysed oxidation.