132972-30-6Relevant academic research and scientific papers
Novel hybrids derived from aspirin and chalcones potently suppress colorectal cancer in vitro and in vivo
Lu, Shan,Obianom, Obinna N.,Ai, Yong
, p. 1722 - 1732 (2018/10/26)
Colorectal cancer (CRC) remains the fourth leading cause of cancer deaths around the world despite the availability of many approved small molecules for treatment. The issues lie in the potency, selectivity and targeting of these compounds. Therefore, new
Synthesis, and antibacterial activity of novel 4,5-dihydro-1H-pyrazole derivatives as DNA gyrase inhibitors
Liu, Jia-Jia,Sun, Juan,Fang, Yun-Bin,Yang, Yong-An,Jiao, Rui-Hua,Zhu, Hai-Liang
, p. 998 - 1008 (2014/02/14)
A series of novel 4,5-dihydropyrazole derivatives (4a-4t), containing the dinitrobenzotrifluoride moiety, as DNA gyrase inhibitors were designed and synthesized. Based on the preliminary results, compounds 4d, 4h and 4t with potent inhibitory activity in
