1329792-70-2

Basic information

• Product Name: N-Benzyl (-)-NorMacroMerine
• Synonyms: N-Benzyl (-)-NorMacroMerine;(αR)-3,4-DiMethoxy-α-[(benzylMethylaMino)Methyl]benzeneMethanol
• CAS NO: 1329792-70-2
• Molecular Formula: C18H23NO3
• Molecular Weight: 301.38012
• Product Categories: Amines;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1329792-70-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Benzyl (-)-NorMacroMerine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl (-)-NorMacroMerine(1329792-70-2)
• EPA Substance Registry System: N-Benzyl (-)-NorMacroMerine(1329792-70-2)

Safety Data

• Hazardous Substances Data: 1329792-70-2(Hazardous Substances Data)

Usage

Uses

Protected Normacromerine.

Upstream product

• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 103-67-3 benzyl-methyl-amine 
• 1835-02-5 2-Bromo-1-(3,4-dimethoxyphenyl)ethanone 
• 33342-73-3 α-(N-methyl-N-benzylamino)-3,4-dimethoxyacetophenone 

Downstream Products

• 25836-15-1 2-methyl-4-(3',4'-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide 

Relevant articles and documents

Dopamine Agonist Properties of N-Alkyl-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines

A series of homologous N-alkyl-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines was synthesized and examined for a dopamine-like ability to dilate the renal artery.The N-methyl derivative was equipotent to the 3',4'-dihydroxy derivative of the antidepressant agent nomifensine, indicating that the 8-amino group of the latter is not essential for dopamine-like activity.The N-ethyl homologue was reduced in potency when compared to the N-methyl, and the N-n-propyl, surprisingly, was essentially devoid of activity.This was unexpected in view of the fact that in all series of dopamine-like agents reported to date, N-alkylation, when one of the alkyls was an n-propyl group, either allowed retention or enhancement of potency.