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1329793-44-3

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1329793-44-3 Usage

Description

(R)-(-)-CaMptothecin-d5, also known as labeled (R)-(-)-Camptothecin (C175145), is an antitumor alkaloid derived from the Camptotheca acuminata tree. It exhibits potent cytotoxic properties and is widely recognized for its antitumor activity. The compound binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and trapping the enzyme in a covalent linkage with DNA.

Uses

Used in Anticancer Applications:
(R)-(-)-CaMptothecin-d5 is used as an antineoplastic agent for its ability to inhibit the reassociation of DNA after cleavage by topoisomerase I, leading to the prevention of cancer cell replication and proliferation. This action makes it a potent cytotoxic antitumor agent, effective against various types of cancer.
Used in Pharmaceutical Industry:
(R)-(-)-CaMptothecin-d5 is used as a key component in the development of novel cancer therapeutics due to its unique mechanism of action. Its irreversible binding to the DNA-topoisomerase I complex provides a distinct advantage in targeting cancer cells while minimizing damage to healthy cells.
Used in Research and Development:
In the field of biomedical research, (R)-(-)-CaMptothecin-d5 serves as an essential tool for studying the mechanisms of DNA repair, topoisomerase I function, and the development of resistance to cancer treatments. Its use in research helps to advance our understanding of cancer biology and contributes to the development of more effective cancer therapies.
Used in Drug Delivery Systems:
Similar to gallotannin, (R)-(-)-CaMptothecin-d5 can also benefit from novel drug delivery systems to enhance its applications and efficacy against cancer cells. Various organic and metallic nanoparticles can be employed as carriers for (R)-(-)-CaMptothecin-d5 delivery, aiming to improve its delivery, bioavailability, and therapeutic outcomes.

Check Digit Verification of cas no

The CAS Registry Mumber 1329793-44-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,2,9,7,9 and 3 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1329793-44:
(9*1)+(8*3)+(7*2)+(6*9)+(5*7)+(4*9)+(3*3)+(2*4)+(1*4)=193
193 % 10 = 3
So 1329793-44-3 is a valid CAS Registry Number.

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