132997-52-5Relevant academic research and scientific papers
Selective Monoarylation of Primary Amines Using the Pd-PEPPSI-IPentCl Precatalyst
Sharif, Sepideh,Rucker, Richard P.,Chandrasoma, Nalin,Mitchell, David,Rodriguez, Michael J.,Froese, Robert D. J.,Organ, Michael G.
, p. 9507 - 9511 (2015)
A single set of reaction conditions for the palladium-catalyzed amination of a wide variety of (hetero)aryl halides using primary alkyl amines has been developed. By combining the exceptionally high reactivity of the Pd-PEPPSI-IPentCl catalyst (PEPPSI=pyridine enhanced precatalyst preparation, stabilization, and initiation) with the soluble and nonaggressive sodium salt of BHT (BHT=2,6-di-tert-butyl-hydroxytoluene), both six- and five-membered (hetero)aryl halides undergo efficient and selective amination.
Substituted 4-amino-isoquinoline compounds, pharmaceutical composition and method of use
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, (2008/06/13)
Isoquinoline compounds, compositions containing them and their use in the inhibition of gastric acid secretion in mammals. A compound of the invention is 1-[(2-Methoxyphenylmethyl)amino]isoquinoline hydrochloride.
