1329998-91-5

Basic information

• Product Name: C₃₆H₅₀F₄N₄O₇
• Synonyms: C₃₆H₅₀F₄N₄O₇
• CAS NO: 1329998-91-5
• Molecular Weight: 726.809
• Mol File: 1329998-91-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₆H₅₀F₄N₄O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₆H₅₀F₄N₄O₇(1329998-91-5)
• EPA Substance Registry System: C₃₆H₅₀F₄N₄O₇(1329998-91-5)

Safety Data

• Hazardous Substances Data: 1329998-91-5(Hazardous Substances Data)

Upstream product

• 114214-49-2 1-tert-butoxycarbonyl-3,4-epoxypyrrolidine 
• 1329998-83-5 (3R,4R)-tert-butyl 3-(allyloxy)-4-((6-(bis(tert-butoxycarbonyl)-amino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate 
• 1329998-82-4 (3R,4R)-tert-butyl 3-((6-(N,N-di-tert-butyl-amino)-4-methylpyridin-2-yl)methyl)-4-(((1S,4R)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl)oxy)pyrrolidine-1-carboxylate 
• 1237495-45-2 (3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-oxoethoxy)pyrrolidine-1-carboxylate 
• 1329998-85-7 C₈H₇F₄N*ClH 
• 1221064-97-6 (3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-hydroxypyrrolidine-1-carboxylate 
• 848472-36-6 tert-butyl (4,6-dimethylpyridin-2-yl)carbamate 

Relevant articles and documents

Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase

We report an efficient synthetic route to chiral pyrrolidine inhibitors of neuronal nitric oxide synthase (nNOS) and crystal structures of the inhibitors bound to nNOS and to endothelial NOS. The new route enables versatile structure-activity relationship studies on the pyrrolidine-based scaffold, which can be beneficial for further development of nNOS inhibitors. The X-ray crystal structures of five new fluorine-containing inhibitors bound to nNOS provide insights into the effect of the fluorine atoms on binding.