CZC-25146 hydrochloride is a chemical compound that functions as a potent and selective antagonist of the N-methyl-D-aspartate (NMDA) receptor, a key player in synaptic plasticity and memory formation. It modulates the activity of glutamate, the primary excitatory neurotransmitter in the central nervous system, and has been explored for its therapeutic potential in various neurological and psychiatric conditions.
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Basic information
- Product Name: CZC-25146 hydrochloride
- Synonyms: CZC-25146 hydrochloride;CZC-25146.HCl;N-[2-[[5-Fluoro-2-[[2-Methoxy-4-(4-Morpholinyl)phenyl]aMino]-4-pyriMidinyl]aMino]phenyl]-MethanesulfonaMide hydrochloride
- CAS NO:1330003-04-7
- Molecular Formula: C22H26ClFN6O4S
- Molecular Weight: 524.9960432
- EINECS: 604-604-1
- Product Categories: N/A
- Mol File: 1330003-04-7.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: white to beige/
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: DMSO: >15mg/mL (warmed)
- CAS DataBase Reference: CZC-25146 hydrochloride(CAS DataBase Reference)
- NIST Chemistry Reference: CZC-25146 hydrochloride(1330003-04-7)
- EPA Substance Registry System: CZC-25146 hydrochloride(1330003-04-7)
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Safety Data
- Hazard Codes: T,Xi
- Statements: 25-36
- Safety Statements: 26-45
- RIDADR: UN 2811 6.1 / PGIII
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1330003-04-7(Hazardous Substances Data)
1330003-04-7 Usage
Uses
Used in Pharmaceutical Industry:CZC-25146 hydrochloride is used as a therapeutic agent for the treatment of neurological and psychiatric disorders. Its application is based on its ability to block the NMDA receptor, which is implicated in the pathophysiology of conditions such as schizophrenia, depression, and neurodegenerative diseases.
Used in Pain Management:
CZC-25146 hydrochloride is used as an analgesic agent for modulating pain perception. Its role in this context has shown promising results in preclinical studies, indicating its potential to alleviate pain by interfering with the excitatory neurotransmission mediated by the NMDA receptor.
Used in Research Applications:
CZC-25146 hydrochloride is used as a research tool for studying the role of NMDA receptors in synaptic plasticity, memory formation, and the mechanisms underlying various neurological and psychiatric disorders. Its selectivity and potency make it a valuable compound for investigating the complex interactions of glutamate signaling in the central nervous system.
Check Digit Verification of cas no
The CAS Registry Mumber 1330003-04-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,0,0,0 and 3 respectively; the second part has 2 digits, 0 and 4 respectively.Calculate Digit Verification of CAS Registry Number 1330003-04:
(9*1)+(8*3)+(7*3)+(6*0)+(5*0)+(4*0)+(3*3)+(2*0)+(1*4)=67
67 % 10 = 7
So 1330003-04-7 is a valid CAS Registry Number.
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CZC-25146 hydrochloride
