1330059-93-2

Basic information

• Product Name: C₂₇H₂₇N₃O₂
• Synonyms: C₂₇H₂₇N₃O₂
• CAS NO: 1330059-93-2
• Molecular Weight: 425.53
• Mol File: 1330059-93-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₂₇N₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₂₇N₃O₂(1330059-93-2)
• EPA Substance Registry System: C₂₇H₂₇N₃O₂(1330059-93-2)

Safety Data

• Hazardous Substances Data: 1330059-93-2(Hazardous Substances Data)

Upstream product

• 2385-87-7 d-Lysergic acid pyrrolidide 
• 82-58-6 D-lysergic acid 
• 66186-85-4 1-(9,10-didehydro-ergolin-8-carbonyl)-pyrrolidine 
• 103-80-0 phenylacetyl chloride 

Relevant articles and documents

Special ergolines efficiently inhibit the chemokine receptor CXCR3 in blood

The structure-activity relationship of highly potent special ergolines which selectively block the chemokine receptor CXCR3 is reported. The most potent compounds showed IC50 values below 10 nM in both ligand binding and Ca2+-mobilization assays. However, these compounds were poorly active in an assay that measures receptor occupancy in blood. Introduction of polar substituents led to derivatives with IC50 values below 10 nM in this assay. Among them was compound 11a which showed both a favorable PK profile and cross reactivity with rodent CXCR3 making it a promising tool compound to further explore the role of CXCR3 in animal models.