13301-77-4

Upstream product

• 1075-77-0 4-chlorocinnamaldehyde 

Downstream Products

• 1352755-98-6 (R)-5-acetyl-4-(4-chlorophenyl)-6-methyl-3,4-dihydro-2H-pyran-2-one 
• 1352755-83-9 (S)-5-acetyl-4-(4-chlorophenyl)-6-methyl-3,4-dihydro-2H-pyran-2-one 
• 24393-52-0 ethyl (E)-3-(4-chlorophenyl)prop-2-enoate 
• 633284-20-5 4-(4-chlorophenyl)-7,7-dimethyl-1-phenyl-3,4,7,8-tetrahydroquinoline-2,5(1H,6H)-dione 
• 1629135-44-9 (R)-5-acetyl-4-(4-chlorophenyl)-3,4-dihydropyrano[3,2-b]indol-2(5H)-one 
• 1629135-32-5 (S)-5-acetyl-4-(4-chlorophenyl)-3,4-dihydropyrano[3,2-b]indol-2(5H)-one 
• 1097651-67-6 5-(4-chlorophenyl)-2-phenylpyrazolidin-3-one 
• 897665-06-4 5-(4-chlorophenyl)-1-phenylpyrazolidin-3-one 

Relevant academic research and scientific papers

Reactions of α-haloacroleins with azides: Highly regioselective synthesis of formyl triazoles

A general metal-free route to 1,4-disubstituted and 1,4,5-trisubstituted 1,2,3-triazoles was developed. α-Haloacroleins reacted with organic azides in a DMSO/H2O mixture solvent at room temperature to produce 1,4-disubstituted triazoles (up to 99%) with exclusive regioselectivities. This protocol is convenient and scalable with a broad substrate scope including aliphatic and aromatic azides. The resulting triazoles exhibited an aldehyde group at the C4 position and demonstrated synthetic utilizations. One 1,2,3-triazole compound containing diastereotopic protons was also identified.