1330187-55-7Relevant academic research and scientific papers
Synthesis of 2-oxoazetidine derivatives of 2-aminothiazole and their biological activity
Samadhiya, Pushkal,Sharma, Ritu,Srivastava, Santosh K.,Srivastava, Savitri D.
, p. 599 - 605 (2012/10/29)
A new series of 3-chloro-4-(substituted phenyl)-1-{[2-(2-thiazolylamino) ethyl]amino}-2-azetidinone, compounds 4a-m, has been synthesized from 2-aminothiazole as the starting material. The structures of all the synthesized compounds were confirmed by chemical and spectral analyses, such as FTIR, 1H-NMR and 13C-NMR spectroscopy. All the final synthesized compounds 4a-m were screened for their antibacterial and antifungal activities against some selected bacteria and fungi and for their antitubercular activity against Mycobacterium tuberculosis, and their minimum inhibitory concentration (MIC) values were determined. The anti-inflammatory activities of the title compounds were screened using albino rats (either sex) and gave acceptable results. 2012 Copyright (CC) SCS.
Synthesis and biological study of some 4-oxo-thiazolidine derivatives of 2-aminothiazole
Samadhiya, Pushkal,Sharma, Ritu,Srivastava, Santosh K.,Srivastava, Savitri D.
experimental part, p. 1001 - 1010 (2012/01/05)
Conventional and microwave assisted synthesis of new series of N-[2-{2-(substituted phenyl)-4-oxo-5-(substituted benzylidene)-1,3-thiazolidine} -iminoethyl]-2-aminothiazole 5a - 5m have been developed. The cycloaddition reaction of thioglycolic acid with N-{2-(substituted benzylidenehydrazino)- ethyl}-2-aminothiazole 3a - 3m in the presence of anhydrous ZnCl2 afforded new heterocyclic compounds N-[2-{2-(substituted phenyl)-4-oxo-1,3-thiazolidine}- iminoethyl]-2-aminothiazole 4a - 4m. The later product on treatment with several selected substituted aromatic aldehydes in the presence of C2H 5ONa undergoes Knoevenagel reaction to yield 5a - 5m. The structures of compounds 1, 2, 3a - 3m, 4a - 4m and 5a - 5m were confirmed by IR, 1H NMR, 13C NMR, FAB-Mass and chemical analysis. All above compounds were screened for their antimicrobial activities against some selected bacteria and fungi and antituberculosis study against M. tuberculosis.
