1330187-89-7Relevant academic research and scientific papers
Synthesis and biological study of some 4-oxo-thiazolidine derivatives of 2-aminothiazole
Samadhiya, Pushkal,Sharma, Ritu,Srivastava, Santosh K.,Srivastava, Savitri D.
, p. 1001 - 1010 (2012/01/05)
Conventional and microwave assisted synthesis of new series of N-[2-{2-(substituted phenyl)-4-oxo-5-(substituted benzylidene)-1,3-thiazolidine} -iminoethyl]-2-aminothiazole 5a - 5m have been developed. The cycloaddition reaction of thioglycolic acid with N-{2-(substituted benzylidenehydrazino)- ethyl}-2-aminothiazole 3a - 3m in the presence of anhydrous ZnCl2 afforded new heterocyclic compounds N-[2-{2-(substituted phenyl)-4-oxo-1,3-thiazolidine}- iminoethyl]-2-aminothiazole 4a - 4m. The later product on treatment with several selected substituted aromatic aldehydes in the presence of C2H 5ONa undergoes Knoevenagel reaction to yield 5a - 5m. The structures of compounds 1, 2, 3a - 3m, 4a - 4m and 5a - 5m were confirmed by IR, 1H NMR, 13C NMR, FAB-Mass and chemical analysis. All above compounds were screened for their antimicrobial activities against some selected bacteria and fungi and antituberculosis study against M. tuberculosis.
