133025-92-0

Basic information

• Product Name: 2-[4-(2-AMINO-ETHYL)-PHENOXY]-N,N-DIETHYL-ACETAMIDE
• Synonyms: 2-[4-(2-AMINO-ETHYL)-PHENOXY]-N,N-DIETHYL-ACETAMIDE
• CAS NO: 133025-92-0
• Molecular Formula: C₁₄H₂₂N₂O₂
• Molecular Weight: 250.34
• Mol File: 133025-92-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[4-(2-AMINO-ETHYL)-PHENOXY]-N,N-DIETHYL-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(2-AMINO-ETHYL)-PHENOXY]-N,N-DIETHYL-ACETAMIDE(133025-92-0)
• EPA Substance Registry System: 2-[4-(2-AMINO-ETHYL)-PHENOXY]-N,N-DIETHYL-ACETAMIDE(133025-92-0)

Safety Data

• Hazardous Substances Data: 133025-92-0(Hazardous Substances Data)

Usage

General Description

2-[4-(2-AMINO-ETHYL)-PHENOXY]-N,N-DIETHYL-ACETAMIDE is a chemical compound with a molecular formula C14H22N2O2. It is a synthetic compound that belongs to the class of amides. 2-[4-(2-AMINO-ETHYL)-PHENOXY]-N,N-DIETHYL-ACETAMIDE contains a phenoxy group, an aminoethyl group, and two diethyl groups. It is used in pharmaceutical research as a potential drug candidate due to its structure and properties, and it may have potential applications in the development of therapeutic agents for various medical conditions. 2-[4-(2-AMINO-ETHYL)-PHENOXY]-N,N-DIETHYL-ACETAMIDE's structure and properties make it a subject of interest in the field of medicinal chemistry and drug discovery.

Upstream product

• 29655-46-7 N-benzyloxycarbonyl-2-(4-hydroxyphenyl)ethylamine 
• 51-67-2 tyrosamine 
• 245078-44-8 N,N-diethyl-2-(4-(2-N-benzyloxycarbamyllethyl)phenoxy)acetamide 

Downstream Products

• 46843-08-7 N,N-diethyl-2-(4-(2-aminoethyl)phenoxy)ethylamine 

Relevant articles and documents

Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists

A novel series of N-(phenylalkyl)cinnamides related to N-(4- phenylbutyl)-3,4-dihydroxy-β-cyanocinnamide (6, an EGFR-K inhibitor with high antiproliferative activity) was synthesized and tested for antagonism at N-methyl-D-aspartate (NMDA) receptor subtypes. Potency and subunit selectivity were assayed by electrical recordings in Xenopus oocytes expressing three binary combinations of cloned rat NMDA receptor subunits: NR1A expressed in combination with either NR2A, NR2B, or NR2C. The N- (phenylalkyl)cinnamides are selective antagonists of NR1(A)/2B receptors. Assayed under steady-state conditions, N-(4-phenylbutyl)-4-hydroxycinnamide (16) has an IC50 value of 77 nM and > 1000-fold selectivity with respect to NR1(A)/2A and NR1(A)/2C receptors. Potency at α1 adrenergic receptors is low for the four cinnamides tested. Inhibition of NR1(A)/2B receptors does not correlate with EGFR and ErbB2/neu tyrosine kinase inhibitor activity. The N-(phenylalkyl)cinnamide series we describe provides a novel and structurally diverse framework for designing new NR2B-selective NMDA antagonists as potential CNS therapeutics.